Cargando…

MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways

Microglial activation and sustained inflammation in the brain can lead to neuronal damage. Hence, limiting microglial activation and brain inflammation is a good therapeutic strategy for inflammatory-associated central nervous disease. MiR-146a is a promising therapeutic microRNA, since it can negat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Guang-Jie, Zhang, Qing-Rong, Gao, Xuan, Wang, Han, Tao, Tao, Gao, Yong-Yue, Zhou, Yan, Chen, Xiang-Xin, Li, Wei, Hang, Chun-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147172/ https://www.ncbi.nlm.nih.gov/pubmed/32317924 http://dx.doi.org/10.3389/fnins.2020.00311

Ejemplares similares

miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2014)

Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2023)

Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF-αB Signaling
por: Yang, Guang, et al.
Publicado: (2020)

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes
por: Hung, Pei-Shi, et al.
Publicado: (2013)

Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
por: Zhang, Quan-Bo, et al.
Publicado: (2018)

miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression
por: An, Rui, et al.
Publicado: (2018)

Effects of acupuncture on the miR-146a-mediated IRAK1/TRAF6/NF-κB signaling pathway in rats with sarcopenia induced by D-galactose
por: Jin, Jing, et al.
Publicado: (2023)

MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression
por: Wei, Jinsong, et al.
Publicado: (2016)

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke
por: Zhang, Zhongfei, et al.
Publicado: (2021)

MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
por: Han, Ruifang, et al.
Publicado: (2023)

MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection
por: Fei, Yanru, et al.
Publicado: (2020)

Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis
por: Zhu, Yunfeng, et al.
Publicado: (2017)

miR-146a reduces depressive behavior by inhibiting microglial activation
por: Liu, Chuan-Peng, et al.
Publicado: (2021)

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis
por: Zhou, Meng, et al.
Publicado: (2023)

miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6
por: Pu, Jieying, et al.
Publicado: (2017)

miR‑146a‑5p negatively regulates the IL‑1β‑stimulated inflammatory response via downregulation of the IRAK1/TRAF6 signaling pathway in human intestinal epithelial cells
por: Li, Yanli, et al.
Publicado: (2022)

MicroRNA-146a Represses Mycobacteria-Induced Inflammatory Response and Facilitates Bacterial Replication via Targeting IRAK-1 and TRAF-6
por: Li, Shuo, et al.
Publicado: (2013)

miR-146b-5p promotes colorectal cancer progression by targeting TRAF6
por: Shi, Liangpan, et al.
Publicado: (2022)

Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury
por: Liu, Guang-Jie, et al.
Publicado: (2020)

miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18
por: Liu, Hui, et al.
Publicado: (2018)

miR-146a-5p Plays an Oncogenic Role in NSCLC via Suppression of TRAF6
por: Liu, Xiangdong, et al.
Publicado: (2020)

miR-146-5p restrains calcification of vascular smooth muscle cells by suppressing TRAF6
por: Yang, Jing, et al.
Publicado: (2022)

LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling
por: Wang, Li-Qing, et al.
Publicado: (2018)

Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway
por: Wang, Zhiyao, et al.
Publicado: (2018)

MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1
por: Li, Qiankun, et al.
Publicado: (2023)

Downregulation of miR-146a-5p Promotes Acute Pancreatitis through Activating the TLR9/NLRP3 Signaling Pathway by Targeting TRAF6 In Vitro Rat Model
por: Deng, Dehai, et al.
Publicado: (2022)

Combination of TLR agonist and miR146a mimics attenuates ovalbumin-induced asthma
por: Wang, Xinhua, et al.
Publicado: (2020)

miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas
por: Liu, Jing, et al.
Publicado: (2015)

miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway
por: Liu, Yi-Nan, et al.
Publicado: (2020)

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis
por: Wen, Silu, et al.
Publicado: (2023)

Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling
por: Gao, Wei, et al.
Publicado: (2021)

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma
por: Qiu, Zhenwei, et al.
Publicado: (2017)

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State
por: Saba, Reuben, et al.
Publicado: (2012)

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway
por: Landais, Igor, et al.
Publicado: (2015)

MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells
por: Han, Peifeng, et al.
Publicado: (2023)

Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion
por: Ding, Jinli, et al.
Publicado: (2021)

Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice
por: Zhang, Yi, et al.
Publicado: (2022)

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
por: Lin, Su-Chang, et al.
Publicado: (2010)

Bioinformatic analysis of the ssc-miR-146b upstream promoter region
por: Tao, Xin, et al.
Publicado: (2015)

MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation
por: Liu, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qr333ftihuds8re477tkrhah00