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Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial
OBJECTIVES: In the phase II FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses (FORWARD) study, sprifermin demonstrated cartilage modification in the total femorotibial joint and in both femorotibial compartments by MRI in patients with knee osteoarthritis. Here, we evaluat...
Autores principales: | Eckstein, Felix, Kraines, Jeffrey L, Aydemir, Aida, Wirth, Wolfgang, Maschek, Susanne, Hochberg, Marc C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147175/ https://www.ncbi.nlm.nih.gov/pubmed/32098758 http://dx.doi.org/10.1136/annrheumdis-2019-216453 |
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