Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings

We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 15:01. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephr...

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Detalles Bibliográficos
Autores principales: Durcan, Martin E, Nair, Beena, Anderton, John G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147311/
https://www.ncbi.nlm.nih.gov/pubmed/32296530
http://dx.doi.org/10.1093/ckj/sfz058
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author Durcan, Martin E
Nair, Beena
Anderton, John G
author_facet Durcan, Martin E
Nair, Beena
Anderton, John G
author_sort Durcan, Martin E
collection PubMed
description We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 15:01. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephritis. Her brother had presented 6 years earlier with oligoanuric acute kidney injury. He was dual positive for MPO ANCA and anti-GBM antibodies. Renal biopsy was not performed. Both had an absence of pulmonary involvement. Tissue typing confirmed both were heterozygous for HLA DRB1 15:01 and DRB1 04:03.
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spelling pubmed-71473112020-04-15 Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings Durcan, Martin E Nair, Beena Anderton, John G Clin Kidney J Exceptional Case We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 15:01. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephritis. Her brother had presented 6 years earlier with oligoanuric acute kidney injury. He was dual positive for MPO ANCA and anti-GBM antibodies. Renal biopsy was not performed. Both had an absence of pulmonary involvement. Tissue typing confirmed both were heterozygous for HLA DRB1 15:01 and DRB1 04:03. Oxford University Press 2019-06-03 /pmc/articles/PMC7147311/ /pubmed/32296530 http://dx.doi.org/10.1093/ckj/sfz058 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Case
Durcan, Martin E
Nair, Beena
Anderton, John G
Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title_full Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title_fullStr Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title_full_unstemmed Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title_short Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
title_sort human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings
topic Exceptional Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147311/
https://www.ncbi.nlm.nih.gov/pubmed/32296530
http://dx.doi.org/10.1093/ckj/sfz058
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