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Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water

We previously reported chronic respiratory effects in children who were then 7–17 years of age in Matlab, Bangladesh. One group of children had been exposed to high concentrations of arsenic in drinking water in utero and early childhood (average 436 µg/L), and the other group of children were never...

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Autores principales: Khan, Md Alfazal, Hira-Smith, Meera, Ahmed, Syed Imran, Yunus, Mohammad, Hasan, S. M. Tafsir, Liaw, Jane, Balmes, John, Raqib, Rubhana, Yuan, Yan, Kalman, David, Roh, Taehyun, Steinmaus, Craig, Smith, Allan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147401/
https://www.ncbi.nlm.nih.gov/pubmed/32337474
http://dx.doi.org/10.1097/EE9.0000000000000089
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author Khan, Md Alfazal
Hira-Smith, Meera
Ahmed, Syed Imran
Yunus, Mohammad
Hasan, S. M. Tafsir
Liaw, Jane
Balmes, John
Raqib, Rubhana
Yuan, Yan
Kalman, David
Roh, Taehyun
Steinmaus, Craig
Smith, Allan H.
author_facet Khan, Md Alfazal
Hira-Smith, Meera
Ahmed, Syed Imran
Yunus, Mohammad
Hasan, S. M. Tafsir
Liaw, Jane
Balmes, John
Raqib, Rubhana
Yuan, Yan
Kalman, David
Roh, Taehyun
Steinmaus, Craig
Smith, Allan H.
author_sort Khan, Md Alfazal
collection PubMed
description We previously reported chronic respiratory effects in children who were then 7–17 years of age in Matlab, Bangladesh. One group of children had been exposed to high concentrations of arsenic in drinking water in utero and early childhood (average 436 µg/L), and the other group of children were never known to have been exposed to >10 µg/L. The exposed children, both males and females, had marked increases in chronic respiratory symptoms. METHODS: The current study involves a further follow-up of these children now 14–26 years of age with 463 located and agreeing to participate. They were interviewed for respiratory symptoms and lung function was measured. Data were collected on smoking, body mass index (BMI), and number of rooms in the house as a measure of socioeconomic status. RESULTS: Respiratory effects were still present in males but not females. In the high exposure group (>400 µg/L in early life) the odds ratio (OR) among male participants for dry cough in the last 12 months was 2.36 (95% confidence interval [CI] = 1.21, 4.63, P = 0.006) and for asthma OR = 2.51 (95% CI = 1.19, 5.29, P = 0.008). Forced vital capacity (FVC) was reduced in males in the early life high-exposure group compared with those never exposed (−95ml, P = 0.04), but not in female participants. CONCLUSIONS: By the age range 14–26, there was little remaining evidence of chronic respiratory effects in females but pronounced effects persisted in males. Mechanisms for the marked male female differences warrant further investigation along with further follow-up to see if respiratory effects continue in males.
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spelling pubmed-71474012020-04-24 Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water Khan, Md Alfazal Hira-Smith, Meera Ahmed, Syed Imran Yunus, Mohammad Hasan, S. M. Tafsir Liaw, Jane Balmes, John Raqib, Rubhana Yuan, Yan Kalman, David Roh, Taehyun Steinmaus, Craig Smith, Allan H. Environ Epidemiol Original Research Article We previously reported chronic respiratory effects in children who were then 7–17 years of age in Matlab, Bangladesh. One group of children had been exposed to high concentrations of arsenic in drinking water in utero and early childhood (average 436 µg/L), and the other group of children were never known to have been exposed to >10 µg/L. The exposed children, both males and females, had marked increases in chronic respiratory symptoms. METHODS: The current study involves a further follow-up of these children now 14–26 years of age with 463 located and agreeing to participate. They were interviewed for respiratory symptoms and lung function was measured. Data were collected on smoking, body mass index (BMI), and number of rooms in the house as a measure of socioeconomic status. RESULTS: Respiratory effects were still present in males but not females. In the high exposure group (>400 µg/L in early life) the odds ratio (OR) among male participants for dry cough in the last 12 months was 2.36 (95% confidence interval [CI] = 1.21, 4.63, P = 0.006) and for asthma OR = 2.51 (95% CI = 1.19, 5.29, P = 0.008). Forced vital capacity (FVC) was reduced in males in the early life high-exposure group compared with those never exposed (−95ml, P = 0.04), but not in female participants. CONCLUSIONS: By the age range 14–26, there was little remaining evidence of chronic respiratory effects in females but pronounced effects persisted in males. Mechanisms for the marked male female differences warrant further investigation along with further follow-up to see if respiratory effects continue in males. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7147401/ /pubmed/32337474 http://dx.doi.org/10.1097/EE9.0000000000000089 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environment Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Khan, Md Alfazal
Hira-Smith, Meera
Ahmed, Syed Imran
Yunus, Mohammad
Hasan, S. M. Tafsir
Liaw, Jane
Balmes, John
Raqib, Rubhana
Yuan, Yan
Kalman, David
Roh, Taehyun
Steinmaus, Craig
Smith, Allan H.
Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title_full Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title_fullStr Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title_full_unstemmed Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title_short Prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
title_sort prospective cohort study of respiratory effects at ages 14 to 26 following early life exposure to arsenic in drinking water
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147401/
https://www.ncbi.nlm.nih.gov/pubmed/32337474
http://dx.doi.org/10.1097/EE9.0000000000000089
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