Tissue Culture Models

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The use of tissue cultures as a research tool to investigate the pathophysiologic bases of diseases has become essential in the current age of molecular biomedical research. Although it will always be necessary to translate and validate the observations seen in vitro to the patient or animal, the ab...

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Autores principales: Vertrees, Roger A., Goodwin, Thomas, Jordan, Jeffrey M., Zwischenberger, Joseph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147448/
http://dx.doi.org/10.1007/978-0-387-72430-0_15
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author Vertrees, Roger A.
Goodwin, Thomas
Jordan, Jeffrey M.
Zwischenberger, Joseph B.
author_facet Vertrees, Roger A.
Goodwin, Thomas
Jordan, Jeffrey M.
Zwischenberger, Joseph B.
author_sort Vertrees, Roger A.
collection PubMed
description The use of tissue cultures as a research tool to investigate the pathophysiologic bases of diseases has become essential in the current age of molecular biomedical research. Although it will always be necessary to translate and validate the observations seen in vitro to the patient or animal, the ability to investigate the role(s) of individual variables free from confounders is paramount toward increasing our understanding of the physiology of the lung and the role of its cellular components in disease. Additionally, it is not feasible to conduct certain research in humans because of ethical constraints, yet investigators may still be interested in the physiologic response in human tissues; in vitro characterization of human tissue is an acceptable choice.
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spelling pubmed-71474482020-04-10 Tissue Culture Models Vertrees, Roger A. Goodwin, Thomas Jordan, Jeffrey M. Zwischenberger, Joseph B. Molecular Pathology of Lung Diseases Article The use of tissue cultures as a research tool to investigate the pathophysiologic bases of diseases has become essential in the current age of molecular biomedical research. Although it will always be necessary to translate and validate the observations seen in vitro to the patient or animal, the ability to investigate the role(s) of individual variables free from confounders is paramount toward increasing our understanding of the physiology of the lung and the role of its cellular components in disease. Additionally, it is not feasible to conduct certain research in humans because of ethical constraints, yet investigators may still be interested in the physiologic response in human tissues; in vitro characterization of human tissue is an acceptable choice. 2010-05-21 /pmc/articles/PMC7147448/ http://dx.doi.org/10.1007/978-0-387-72430-0_15 Text en © Springer Science+Business Media, LLC. 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Vertrees, Roger A.
Goodwin, Thomas
Jordan, Jeffrey M.
Zwischenberger, Joseph B.
Tissue Culture Models
title Tissue Culture Models
title_full Tissue Culture Models
title_fullStr Tissue Culture Models
title_full_unstemmed Tissue Culture Models
title_short Tissue Culture Models
title_sort tissue culture models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147448/
http://dx.doi.org/10.1007/978-0-387-72430-0_15
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AT goodwinthomas tissueculturemodels
AT jordanjeffreym tissueculturemodels
AT zwischenbergerjosephb tissueculturemodels

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