Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer

It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleu...

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Autores principales: Ponnulakshmi, Rajagopal, Vishnupriya, Veeraraghavan, Mohan, Surapaneni Krishna, Abilasha, Srinivasan, Ramajayam, Govindan, Vijayalakshmi, Periyasamy, Rajalakshmi, Manikkam, Selvaraj, Jayaraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147492/
https://www.ncbi.nlm.nih.gov/pubmed/32308271
http://dx.doi.org/10.6026/97320630016283
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author Ponnulakshmi, Rajagopal
Vishnupriya, Veeraraghavan
Mohan, Surapaneni Krishna
Abilasha, Srinivasan
Ramajayam, Govindan
Vijayalakshmi, Periyasamy
Rajalakshmi, Manikkam
Selvaraj, Jayaraman
author_facet Ponnulakshmi, Rajagopal
Vishnupriya, Veeraraghavan
Mohan, Surapaneni Krishna
Abilasha, Srinivasan
Ramajayam, Govindan
Vijayalakshmi, Periyasamy
Rajalakshmi, Manikkam
Selvaraj, Jayaraman
author_sort Ponnulakshmi, Rajagopal
collection PubMed
description It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.
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spelling pubmed-71474922020-04-17 Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer Ponnulakshmi, Rajagopal Vishnupriya, Veeraraghavan Mohan, Surapaneni Krishna Abilasha, Srinivasan Ramajayam, Govindan Vijayalakshmi, Periyasamy Rajalakshmi, Manikkam Selvaraj, Jayaraman Bioinformation Research Article It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer. Biomedical Informatics 2020-03-31 /pmc/articles/PMC7147492/ /pubmed/32308271 http://dx.doi.org/10.6026/97320630016283 Text en © 2020 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Ponnulakshmi, Rajagopal
Vishnupriya, Veeraraghavan
Mohan, Surapaneni Krishna
Abilasha, Srinivasan
Ramajayam, Govindan
Vijayalakshmi, Periyasamy
Rajalakshmi, Manikkam
Selvaraj, Jayaraman
Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title_full Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title_fullStr Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title_full_unstemmed Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title_short Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
title_sort molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147492/
https://www.ncbi.nlm.nih.gov/pubmed/32308271
http://dx.doi.org/10.6026/97320630016283
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