Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV

The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV...

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Detalles Bibliográficos
Autores principales: Afaq, Sarah, Malik, Arshi, Akhtar, Md.Salman, Alwabli, Afaf S, Alzahrani, Dhafer A, Al-Solami, Habeeb M, Alzahrani, Othman, Alam, Qamre, Kamal, Mohammad Azhar, Abulfaraj, Aala A, Tarique, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147493/
https://www.ncbi.nlm.nih.gov/pubmed/32308264
http://dx.doi.org/10.6026/97320630016223
Descripción
Sumario:The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV is currently limited. Therefore, it is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV. This data is relevant in the design and development of vaccine and other therapeutic candidates for further consideration.

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