Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV

The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV...

Descripción completa

Detalles Bibliográficos
Autores principales: Afaq, Sarah, Malik, Arshi, Akhtar, Md.Salman, Alwabli, Afaf S, Alzahrani, Dhafer A, Al-Solami, Habeeb M, Alzahrani, Othman, Alam, Qamre, Kamal, Mohammad Azhar, Abulfaraj, Aala A, Tarique, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147493/
https://www.ncbi.nlm.nih.gov/pubmed/32308264
http://dx.doi.org/10.6026/97320630016223
_version_ 1783520431545778176
author Afaq, Sarah
Malik, Arshi
Akhtar, Md.Salman
Alwabli, Afaf S
Alzahrani, Dhafer A
Al-Solami, Habeeb M
Alzahrani, Othman
Alam, Qamre
Kamal, Mohammad Azhar
Abulfaraj, Aala A
Tarique, Mohammad
author_facet Afaq, Sarah
Malik, Arshi
Akhtar, Md.Salman
Alwabli, Afaf S
Alzahrani, Dhafer A
Al-Solami, Habeeb M
Alzahrani, Othman
Alam, Qamre
Kamal, Mohammad Azhar
Abulfaraj, Aala A
Tarique, Mohammad
author_sort Afaq, Sarah
collection PubMed
description The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV is currently limited. Therefore, it is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV. This data is relevant in the design and development of vaccine and other therapeutic candidates for further consideration.
format Online
Article
Text
id pubmed-7147493
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Biomedical Informatics
record_format MEDLINE/PubMed
spelling pubmed-71474932020-04-17 Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV Afaq, Sarah Malik, Arshi Akhtar, Md.Salman Alwabli, Afaf S Alzahrani, Dhafer A Al-Solami, Habeeb M Alzahrani, Othman Alam, Qamre Kamal, Mohammad Azhar Abulfaraj, Aala A Tarique, Mohammad Bioinformation Research Article The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV is currently limited. Therefore, it is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV. This data is relevant in the design and development of vaccine and other therapeutic candidates for further consideration. Biomedical Informatics 2020-03-31 /pmc/articles/PMC7147493/ /pubmed/32308264 http://dx.doi.org/10.6026/97320630016223 Text en © 2020 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Afaq, Sarah
Malik, Arshi
Akhtar, Md.Salman
Alwabli, Afaf S
Alzahrani, Dhafer A
Al-Solami, Habeeb M
Alzahrani, Othman
Alam, Qamre
Kamal, Mohammad Azhar
Abulfaraj, Aala A
Tarique, Mohammad
Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title_full Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title_fullStr Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title_full_unstemmed Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title_short Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV
title_sort analysis of predicted proteasomal cleavages in the methyltransferase domain from jev
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147493/
https://www.ncbi.nlm.nih.gov/pubmed/32308264
http://dx.doi.org/10.6026/97320630016223
work_keys_str_mv AT afaqsarah analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT malikarshi analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT akhtarmdsalman analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT alwabliafafs analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT alzahranidhafera analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT alsolamihabeebm analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT alzahraniothman analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT alamqamre analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT kamalmohammadazhar analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT abulfarajaalaa analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev
AT tariquemohammad analysisofpredictedproteasomalcleavagesinthemethyltransferasedomainfromjev

Ejemplares similares