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Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes

BACKGROUND: Diabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM. METHODS: This study recruited consecutive patients who underwent coron...

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Autores principales: Hou, Zhi-Hui, Lu, Bin, Li, Zhen-Nan, An, Yun-Qiang, Gao, Yang, Yin, Wei-Hua, Budoff, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147656/
https://www.ncbi.nlm.nih.gov/pubmed/32149765
http://dx.doi.org/10.1097/CM9.0000000000000733
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author Hou, Zhi-Hui
Lu, Bin
Li, Zhen-Nan
An, Yun-Qiang
Gao, Yang
Yin, Wei-Hua
Budoff, Matthew J.
author_facet Hou, Zhi-Hui
Lu, Bin
Li, Zhen-Nan
An, Yun-Qiang
Gao, Yang
Yin, Wei-Hua
Budoff, Matthew J.
author_sort Hou, Zhi-Hui
collection PubMed
description BACKGROUND: Diabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM. METHODS: This study recruited consecutive patients who underwent coronary computed tomography (CT) angiography (CCTA) between October 2016 and November 2017. Personal information including conventional cardiovascular risk factors was collected. Plaque phenotypes were automatically calculated for volume of different component. The volume of different plaque was compared between DM patients and those without DM. RESULTS: Among 6381 patients, 931 (14.59%) were diagnosed with DM. The prevalence of plaque in DM subjects was higher compared with nondiabetic group significantly (48.34% vs. 33.01%, χ(2) = 81.84, P < 0.001). DM was a significant risk factor for the prevalence of plaque in a multivariate model (odds ratio [OR] = 1.465, 95% CI: 1.258–1.706, P < 0.001). The volume of total plaque and any plaque subtypes in the DM subjects was greater than those in nondiabetic patients significantly (P < 0.001). CONCLUSION: The coronary artery atherosclerotic plaques were significantly higher in diabetic patients than those in non-diabetic patients.
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spelling pubmed-71476562020-04-17 Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes Hou, Zhi-Hui Lu, Bin Li, Zhen-Nan An, Yun-Qiang Gao, Yang Yin, Wei-Hua Budoff, Matthew J. Chin Med J (Engl) Original Articles BACKGROUND: Diabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM. METHODS: This study recruited consecutive patients who underwent coronary computed tomography (CT) angiography (CCTA) between October 2016 and November 2017. Personal information including conventional cardiovascular risk factors was collected. Plaque phenotypes were automatically calculated for volume of different component. The volume of different plaque was compared between DM patients and those without DM. RESULTS: Among 6381 patients, 931 (14.59%) were diagnosed with DM. The prevalence of plaque in DM subjects was higher compared with nondiabetic group significantly (48.34% vs. 33.01%, χ(2) = 81.84, P < 0.001). DM was a significant risk factor for the prevalence of plaque in a multivariate model (odds ratio [OR] = 1.465, 95% CI: 1.258–1.706, P < 0.001). The volume of total plaque and any plaque subtypes in the DM subjects was greater than those in nondiabetic patients significantly (P < 0.001). CONCLUSION: The coronary artery atherosclerotic plaques were significantly higher in diabetic patients than those in non-diabetic patients. Wolters Kluwer Health 2020-04-05 2020-04-05 /pmc/articles/PMC7147656/ /pubmed/32149765 http://dx.doi.org/10.1097/CM9.0000000000000733 Text en Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Original Articles
Hou, Zhi-Hui
Lu, Bin
Li, Zhen-Nan
An, Yun-Qiang
Gao, Yang
Yin, Wei-Hua
Budoff, Matthew J.
Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title_full Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title_fullStr Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title_full_unstemmed Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title_short Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
title_sort quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147656/
https://www.ncbi.nlm.nih.gov/pubmed/32149765
http://dx.doi.org/10.1097/CM9.0000000000000733
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