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Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease
The human gastrointestinal tract accommodates an entire micro-environment for divergent physiologic processes, the dysbiosis of this micro-ecology has a strong inter-action with the pathogenesis of inflammatory bowel disease (IBD). In the past few years, with the advances in the understanding of mic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147659/ https://www.ncbi.nlm.nih.gov/pubmed/32106123 http://dx.doi.org/10.1097/CM9.0000000000000718 |
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author | Yan, Peng-Guang Li, Jing-Nan |
author_facet | Yan, Peng-Guang Li, Jing-Nan |
author_sort | Yan, Peng-Guang |
collection | PubMed |
description | The human gastrointestinal tract accommodates an entire micro-environment for divergent physiologic processes, the dysbiosis of this micro-ecology has a strong inter-action with the pathogenesis of inflammatory bowel disease (IBD). In the past few years, with the advances in the understanding of microbiome, its metabolites and further application of next generation sequencing, analysis of dynamic alteration of gut micro-environment was realized, which provides numerous information beyond simple microbiota structure or metabolites differences under chronic colitis status. The subsequent intervention strategies targeting the modulation of intestinal micro-environment have been explored as a potential therapy. In this review, we will summarize the recent knowledge about multi-dimensional dysbiosis, the inter-action between fungus and bacteria under inflamed mucosa, and the clinical application of probiotics and fecal microbiota transplantation as a promising therapeutic approach in IBD. |
format | Online Article Text |
id | pubmed-7147659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-71476592020-04-17 Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease Yan, Peng-Guang Li, Jing-Nan Chin Med J (Engl) Review Articles The human gastrointestinal tract accommodates an entire micro-environment for divergent physiologic processes, the dysbiosis of this micro-ecology has a strong inter-action with the pathogenesis of inflammatory bowel disease (IBD). In the past few years, with the advances in the understanding of microbiome, its metabolites and further application of next generation sequencing, analysis of dynamic alteration of gut micro-environment was realized, which provides numerous information beyond simple microbiota structure or metabolites differences under chronic colitis status. The subsequent intervention strategies targeting the modulation of intestinal micro-environment have been explored as a potential therapy. In this review, we will summarize the recent knowledge about multi-dimensional dysbiosis, the inter-action between fungus and bacteria under inflamed mucosa, and the clinical application of probiotics and fecal microbiota transplantation as a promising therapeutic approach in IBD. Wolters Kluwer Health 2020-04-05 2020-04-05 /pmc/articles/PMC7147659/ /pubmed/32106123 http://dx.doi.org/10.1097/CM9.0000000000000718 Text en Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Review Articles Yan, Peng-Guang Li, Jing-Nan Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title | Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title_full | Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title_fullStr | Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title_full_unstemmed | Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title_short | Advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
title_sort | advances in the understanding of the intestinal micro-environment and inflammatory bowel disease |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147659/ https://www.ncbi.nlm.nih.gov/pubmed/32106123 http://dx.doi.org/10.1097/CM9.0000000000000718 |
work_keys_str_mv | AT yanpengguang advancesintheunderstandingoftheintestinalmicroenvironmentandinflammatoryboweldisease AT lijingnan advancesintheunderstandingoftheintestinalmicroenvironmentandinflammatoryboweldisease |