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Clinical utility of characterizing intestinal flora in septic kidney injury

The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its p...

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Autores principales: Yuan, Jiao-Jiao, Chang, Xue-Ni, Li, Min, Yuan, Qi-Xi, Yang, Xiao-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147663/
https://www.ncbi.nlm.nih.gov/pubmed/32149763
http://dx.doi.org/10.1097/CM9.0000000000000724
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author Yuan, Jiao-Jiao
Chang, Xue-Ni
Li, Min
Yuan, Qi-Xi
Yang, Xiao-Ling
author_facet Yuan, Jiao-Jiao
Chang, Xue-Ni
Li, Min
Yuan, Qi-Xi
Yang, Xiao-Ling
author_sort Yuan, Jiao-Jiao
collection PubMed
description The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such changes further influence the occurrence and development of AKI. New technology is enabling various detection methods for intestinal flora. Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis, disease progression mechanism, and intestinal flora.
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spelling pubmed-71476632020-04-17 Clinical utility of characterizing intestinal flora in septic kidney injury Yuan, Jiao-Jiao Chang, Xue-Ni Li, Min Yuan, Qi-Xi Yang, Xiao-Ling Chin Med J (Engl) Review Articles The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such changes further influence the occurrence and development of AKI. New technology is enabling various detection methods for intestinal flora. Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis, disease progression mechanism, and intestinal flora. Wolters Kluwer Health 2020-04-05 2020-04-05 /pmc/articles/PMC7147663/ /pubmed/32149763 http://dx.doi.org/10.1097/CM9.0000000000000724 Text en Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Review Articles
Yuan, Jiao-Jiao
Chang, Xue-Ni
Li, Min
Yuan, Qi-Xi
Yang, Xiao-Ling
Clinical utility of characterizing intestinal flora in septic kidney injury
title Clinical utility of characterizing intestinal flora in septic kidney injury
title_full Clinical utility of characterizing intestinal flora in septic kidney injury
title_fullStr Clinical utility of characterizing intestinal flora in septic kidney injury
title_full_unstemmed Clinical utility of characterizing intestinal flora in septic kidney injury
title_short Clinical utility of characterizing intestinal flora in septic kidney injury
title_sort clinical utility of characterizing intestinal flora in septic kidney injury
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147663/
https://www.ncbi.nlm.nih.gov/pubmed/32149763
http://dx.doi.org/10.1097/CM9.0000000000000724
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