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Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition

Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health...

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Autores principales: Nam, Bora, Kim, Soo A., Park, Soo Dong, Kim, Hyeon Ji, Kim, Ji Soo, Bae, Chu Hyun, Kim, Joo Yun, Nam, Woo, Lee, Jung Lyoul, Sim, Jae Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147770/
https://www.ncbi.nlm.nih.gov/pubmed/32275691
http://dx.doi.org/10.1371/journal.pone.0231268
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author Nam, Bora
Kim, Soo A.
Park, Soo Dong
Kim, Hyeon Ji
Kim, Ji Soo
Bae, Chu Hyun
Kim, Joo Yun
Nam, Woo
Lee, Jung Lyoul
Sim, Jae Hun
author_facet Nam, Bora
Kim, Soo A.
Park, Soo Dong
Kim, Hyeon Ji
Kim, Ji Soo
Bae, Chu Hyun
Kim, Joo Yun
Nam, Woo
Lee, Jung Lyoul
Sim, Jae Hun
author_sort Nam, Bora
collection PubMed
description Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition.
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spelling pubmed-71477702020-04-14 Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition Nam, Bora Kim, Soo A. Park, Soo Dong Kim, Hyeon Ji Kim, Ji Soo Bae, Chu Hyun Kim, Joo Yun Nam, Woo Lee, Jung Lyoul Sim, Jae Hun PLoS One Research Article Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition. Public Library of Science 2020-04-10 /pmc/articles/PMC7147770/ /pubmed/32275691 http://dx.doi.org/10.1371/journal.pone.0231268 Text en © 2020 Nam et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nam, Bora
Kim, Soo A.
Park, Soo Dong
Kim, Hyeon Ji
Kim, Ji Soo
Bae, Chu Hyun
Kim, Joo Yun
Nam, Woo
Lee, Jung Lyoul
Sim, Jae Hun
Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title_full Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title_fullStr Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title_full_unstemmed Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title_short Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
title_sort regulatory effects of lactobacillus plantarum hy7714 on skin health by improving intestinal condition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147770/
https://www.ncbi.nlm.nih.gov/pubmed/32275691
http://dx.doi.org/10.1371/journal.pone.0231268
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