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Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147770/ https://www.ncbi.nlm.nih.gov/pubmed/32275691 http://dx.doi.org/10.1371/journal.pone.0231268 |
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author | Nam, Bora Kim, Soo A. Park, Soo Dong Kim, Hyeon Ji Kim, Ji Soo Bae, Chu Hyun Kim, Joo Yun Nam, Woo Lee, Jung Lyoul Sim, Jae Hun |
author_facet | Nam, Bora Kim, Soo A. Park, Soo Dong Kim, Hyeon Ji Kim, Ji Soo Bae, Chu Hyun Kim, Joo Yun Nam, Woo Lee, Jung Lyoul Sim, Jae Hun |
author_sort | Nam, Bora |
collection | PubMed |
description | Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition. |
format | Online Article Text |
id | pubmed-7147770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-71477702020-04-14 Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition Nam, Bora Kim, Soo A. Park, Soo Dong Kim, Hyeon Ji Kim, Ji Soo Bae, Chu Hyun Kim, Joo Yun Nam, Woo Lee, Jung Lyoul Sim, Jae Hun PLoS One Research Article Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition. Public Library of Science 2020-04-10 /pmc/articles/PMC7147770/ /pubmed/32275691 http://dx.doi.org/10.1371/journal.pone.0231268 Text en © 2020 Nam et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nam, Bora Kim, Soo A. Park, Soo Dong Kim, Hyeon Ji Kim, Ji Soo Bae, Chu Hyun Kim, Joo Yun Nam, Woo Lee, Jung Lyoul Sim, Jae Hun Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title_full | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title_fullStr | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title_full_unstemmed | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title_short | Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition |
title_sort | regulatory effects of lactobacillus plantarum hy7714 on skin health by improving intestinal condition |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147770/ https://www.ncbi.nlm.nih.gov/pubmed/32275691 http://dx.doi.org/10.1371/journal.pone.0231268 |
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