Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

In mammalian cells, mitochondrial dysfunction triggers the integrated stress response (ISR), in which eIF2α phosphorylation induces the transcription factor ATF4(1-3). However, how mitochondrial stress is relayed to ATF4 is unknown. We found that HRI is the eIF2α kinase necessary and sufficient for...

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Detalles Bibliográficos
Autores principales: Guo, Xiaoyan, Aviles, Giovanni, Liu, Yi, Tian, Ruilin, Unger, Bret A., Lin, Yu-Hsiu T., Wiita, Arun P., Xu, Ke, Correia, M. Almira, Kampmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147832/
https://www.ncbi.nlm.nih.gov/pubmed/32132707
http://dx.doi.org/10.1038/s41586-020-2078-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147832/
https://www.ncbi.nlm.nih.gov/pubmed/32132707
http://dx.doi.org/10.1038/s41586-020-2078-2

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