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Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response (ISR), in which eIF2α phosphorylation induces the transcription factor ATF4(1-3). However, how mitochondrial stress is relayed to ATF4 is unknown. We found that HRI is the eIF2α kinase necessary and sufficient for...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147832/ https://www.ncbi.nlm.nih.gov/pubmed/32132707 http://dx.doi.org/10.1038/s41586-020-2078-2 |