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Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of sensory neurons with their peripheral and central processes. Most neurons are surrounded by satellite glial cells and the axons are wrapped by myelinating and non-myelinating Schwann cells. Trigeminal neuro...

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Autores principales: Messlinger, Karl, Balcziak, Louis K., Russo, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148261/
https://www.ncbi.nlm.nih.gov/pubmed/32088764
http://dx.doi.org/10.1007/s00702-020-02161-7
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author Messlinger, Karl
Balcziak, Louis K.
Russo, Andrew F.
author_facet Messlinger, Karl
Balcziak, Louis K.
Russo, Andrew F.
author_sort Messlinger, Karl
collection PubMed
description The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of sensory neurons with their peripheral and central processes. Most neurons are surrounded by satellite glial cells and the axons are wrapped by myelinating and non-myelinating Schwann cells. Trigeminal neurons express various neuropeptides, most notably, calcitonin gene-related peptide (CGRP), substance P, and pituitary adenylate cyclase-activating polypeptide (PACAP). Two types of CGRP receptors are expressed in neurons and satellite glia. A variety of other signal molecules like ATP, nitric oxide, cytokines, and neurotrophic factors are released from trigeminal ganglion neurons and signal to neighboring neurons or satellite glial cells, which can signal back to neurons with same or other mediators. This potential cross-talk of signals involves intracellular mechanisms, including gene expression, that can modulate mediators of sensory information, such as neuropeptides, receptors, and neurotrophic factors. From the ganglia cell bodies, which are outside the blood–brain barrier, the mediators are further distributed to peripheral sites and/or to the spinal trigeminal nucleus in the brainstem, where they can affect neural transmission. A major question is how the sensory neurons in the trigeminal ganglion differ from those in the dorsal root ganglion. Despite their functional overlap, there are distinct differences in their ontogeny, gene expression, signaling pathways, and responses to anti-migraine drugs. Consequently, drugs that modulate cross-talk in the trigeminal ganglion can modulate both peripheral and central sensitization, which may potentially be distinct from sensitization mediated in the dorsal root ganglion.
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spelling pubmed-71482612020-04-16 Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators Messlinger, Karl Balcziak, Louis K. Russo, Andrew F. J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Review Article The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of sensory neurons with their peripheral and central processes. Most neurons are surrounded by satellite glial cells and the axons are wrapped by myelinating and non-myelinating Schwann cells. Trigeminal neurons express various neuropeptides, most notably, calcitonin gene-related peptide (CGRP), substance P, and pituitary adenylate cyclase-activating polypeptide (PACAP). Two types of CGRP receptors are expressed in neurons and satellite glia. A variety of other signal molecules like ATP, nitric oxide, cytokines, and neurotrophic factors are released from trigeminal ganglion neurons and signal to neighboring neurons or satellite glial cells, which can signal back to neurons with same or other mediators. This potential cross-talk of signals involves intracellular mechanisms, including gene expression, that can modulate mediators of sensory information, such as neuropeptides, receptors, and neurotrophic factors. From the ganglia cell bodies, which are outside the blood–brain barrier, the mediators are further distributed to peripheral sites and/or to the spinal trigeminal nucleus in the brainstem, where they can affect neural transmission. A major question is how the sensory neurons in the trigeminal ganglion differ from those in the dorsal root ganglion. Despite their functional overlap, there are distinct differences in their ontogeny, gene expression, signaling pathways, and responses to anti-migraine drugs. Consequently, drugs that modulate cross-talk in the trigeminal ganglion can modulate both peripheral and central sensitization, which may potentially be distinct from sensitization mediated in the dorsal root ganglion. Springer Vienna 2020-02-22 2020 /pmc/articles/PMC7148261/ /pubmed/32088764 http://dx.doi.org/10.1007/s00702-020-02161-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Neurology and Preclinical Neurological Studies - Review Article
Messlinger, Karl
Balcziak, Louis K.
Russo, Andrew F.
Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title_full Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title_fullStr Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title_full_unstemmed Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title_short Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
title_sort cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators
topic Neurology and Preclinical Neurological Studies - Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148261/
https://www.ncbi.nlm.nih.gov/pubmed/32088764
http://dx.doi.org/10.1007/s00702-020-02161-7
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