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Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice

Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors b...

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Autores principales: Dombret, Carlos, Naulé, Lydie, Trouillet, Anne-Charlotte, Parmentier, Caroline, Hardin-Pouzet, Hélène, Mhaouty-Kodja, Sakina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148327/
https://www.ncbi.nlm.nih.gov/pubmed/32277160
http://dx.doi.org/10.1038/s41598-020-63427-4
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author Dombret, Carlos
Naulé, Lydie
Trouillet, Anne-Charlotte
Parmentier, Caroline
Hardin-Pouzet, Hélène
Mhaouty-Kodja, Sakina
author_facet Dombret, Carlos
Naulé, Lydie
Trouillet, Anne-Charlotte
Parmentier, Caroline
Hardin-Pouzet, Hélène
Mhaouty-Kodja, Sakina
author_sort Dombret, Carlos
collection PubMed
description Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERβ gene in the nervous system. Mutant males exhibited reduced social interaction with same-sex congeners and impaired aggressive behavior. They also displayed increased locomotor activity, and reduced or unaffected anxiety-state level in three paradigms. However, when mice were exposed to unescapable stress in the forced swim and tail suspension tests, they spent more time immobile and a reduced time in swimming and climbing. These behavioral alterations were associated with unaffected circadian and restraint stress-induced corticosterone levels, and unchanged number of tryptophan hydroxylase 2-immunoreactive neurons in the dorsal raphe. By contrast, reduced mRNA levels of oxytocin and arginine-vasopressin were observed in the bed nucleus of stria terminalis, whereas no changes were detected in the hypothalamic paraventricular nucleus. The neural ERβ is thus involved to different extent levels in social and mood-related behaviors, with a particular action on oxytocin and arginine-vasopressin signaling pathways of the bed nucleus of stria terminalis, yet the involvement of other brain areas cannot be excluded.
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spelling pubmed-71483272020-04-15 Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice Dombret, Carlos Naulé, Lydie Trouillet, Anne-Charlotte Parmentier, Caroline Hardin-Pouzet, Hélène Mhaouty-Kodja, Sakina Sci Rep Article Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERβ gene in the nervous system. Mutant males exhibited reduced social interaction with same-sex congeners and impaired aggressive behavior. They also displayed increased locomotor activity, and reduced or unaffected anxiety-state level in three paradigms. However, when mice were exposed to unescapable stress in the forced swim and tail suspension tests, they spent more time immobile and a reduced time in swimming and climbing. These behavioral alterations were associated with unaffected circadian and restraint stress-induced corticosterone levels, and unchanged number of tryptophan hydroxylase 2-immunoreactive neurons in the dorsal raphe. By contrast, reduced mRNA levels of oxytocin and arginine-vasopressin were observed in the bed nucleus of stria terminalis, whereas no changes were detected in the hypothalamic paraventricular nucleus. The neural ERβ is thus involved to different extent levels in social and mood-related behaviors, with a particular action on oxytocin and arginine-vasopressin signaling pathways of the bed nucleus of stria terminalis, yet the involvement of other brain areas cannot be excluded. Nature Publishing Group UK 2020-04-10 /pmc/articles/PMC7148327/ /pubmed/32277160 http://dx.doi.org/10.1038/s41598-020-63427-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dombret, Carlos
Naulé, Lydie
Trouillet, Anne-Charlotte
Parmentier, Caroline
Hardin-Pouzet, Hélène
Mhaouty-Kodja, Sakina
Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_full Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_fullStr Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_full_unstemmed Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_short Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
title_sort effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148327/
https://www.ncbi.nlm.nih.gov/pubmed/32277160
http://dx.doi.org/10.1038/s41598-020-63427-4
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