Cargando…
Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spe...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148486/ https://www.ncbi.nlm.nih.gov/pubmed/32192170 http://dx.doi.org/10.3390/antibiotics9030126 |
_version_ | 1783520603624439808 |
---|---|
author | Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Sudarman, Enge Köck, Matthias Wink, Joachim Stadler, Marc |
author_facet | Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Sudarman, Enge Köck, Matthias Wink, Joachim Stadler, Marc |
author_sort | Primahana, Gian |
collection | PubMed |
description | During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of 4 was determined by using the modified Mosher method. Nonocarboline B (2) displayed moderate antifungal activity against Mucor hiemalis, while nonocarboline D (4) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC(50) value of 1.7 µM. |
format | Online Article Text |
id | pubmed-7148486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71484862020-04-21 Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Sudarman, Enge Köck, Matthias Wink, Joachim Stadler, Marc Antibiotics (Basel) Article During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of 4 was determined by using the modified Mosher method. Nonocarboline B (2) displayed moderate antifungal activity against Mucor hiemalis, while nonocarboline D (4) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC(50) value of 1.7 µM. MDPI 2020-03-17 /pmc/articles/PMC7148486/ /pubmed/32192170 http://dx.doi.org/10.3390/antibiotics9030126 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Sudarman, Enge Köck, Matthias Wink, Joachim Stadler, Marc Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title | Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title_full | Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title_fullStr | Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title_full_unstemmed | Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title_short | Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia |
title_sort | nonocarbolines a–e, β-carboline antibiotics produced by the rare actinobacterium nonomuraea sp. from indonesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148486/ https://www.ncbi.nlm.nih.gov/pubmed/32192170 http://dx.doi.org/10.3390/antibiotics9030126 |
work_keys_str_mv | AT primahanagian nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT risdianchandra nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT mozeftjandrawati nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT sudarmanenge nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT kockmatthias nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT winkjoachim nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia AT stadlermarc nonocarbolinesaebcarbolineantibioticsproducedbytherareactinobacteriumnonomuraeaspfromindonesia |