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Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia

During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spe...

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Autores principales: Primahana, Gian, Risdian, Chandra, Mozef, Tjandrawati, Sudarman, Enge, Köck, Matthias, Wink, Joachim, Stadler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148486/
https://www.ncbi.nlm.nih.gov/pubmed/32192170
http://dx.doi.org/10.3390/antibiotics9030126
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author Primahana, Gian
Risdian, Chandra
Mozef, Tjandrawati
Sudarman, Enge
Köck, Matthias
Wink, Joachim
Stadler, Marc
author_facet Primahana, Gian
Risdian, Chandra
Mozef, Tjandrawati
Sudarman, Enge
Köck, Matthias
Wink, Joachim
Stadler, Marc
author_sort Primahana, Gian
collection PubMed
description During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of 4 was determined by using the modified Mosher method. Nonocarboline B (2) displayed moderate antifungal activity against Mucor hiemalis, while nonocarboline D (4) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC(50) value of 1.7 µM.
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spelling pubmed-71484862020-04-21 Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Sudarman, Enge Köck, Matthias Wink, Joachim Stadler, Marc Antibiotics (Basel) Article During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to produce five unprecedented β-carboline derivatives, nonocarbolines A–E (1–5). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of 4 was determined by using the modified Mosher method. Nonocarboline B (2) displayed moderate antifungal activity against Mucor hiemalis, while nonocarboline D (4) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC(50) value of 1.7 µM. MDPI 2020-03-17 /pmc/articles/PMC7148486/ /pubmed/32192170 http://dx.doi.org/10.3390/antibiotics9030126 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Primahana, Gian
Risdian, Chandra
Mozef, Tjandrawati
Sudarman, Enge
Köck, Matthias
Wink, Joachim
Stadler, Marc
Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title_full Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title_fullStr Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title_full_unstemmed Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title_short Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia
title_sort nonocarbolines a–e, β-carboline antibiotics produced by the rare actinobacterium nonomuraea sp. from indonesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148486/
https://www.ncbi.nlm.nih.gov/pubmed/32192170
http://dx.doi.org/10.3390/antibiotics9030126
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