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Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I

Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail. We investigated the pre-stroke PA level in re...

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Autores principales: Åberg, N. David, Gadd, Gustaf, Åberg, Daniel, Hällgren, Peter, Blomstrand, Christian, Jood, Katarina, Nilsson, Michael, Walker, Fredrick R., Svensson, Johan, Jern, Christina, Isgaard, Jörgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148508/
https://www.ncbi.nlm.nih.gov/pubmed/32143318
http://dx.doi.org/10.3390/biomedicines8030052
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author Åberg, N. David
Gadd, Gustaf
Åberg, Daniel
Hällgren, Peter
Blomstrand, Christian
Jood, Katarina
Nilsson, Michael
Walker, Fredrick R.
Svensson, Johan
Jern, Christina
Isgaard, Jörgen
author_facet Åberg, N. David
Gadd, Gustaf
Åberg, Daniel
Hällgren, Peter
Blomstrand, Christian
Jood, Katarina
Nilsson, Michael
Walker, Fredrick R.
Svensson, Johan
Jern, Christina
Isgaard, Jörgen
author_sort Åberg, N. David
collection PubMed
description Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail. We investigated the pre-stroke PA level in relation to the post-stroke serum IGF-I (s-IGF-I) level, at baseline and at 3 months after the index stroke, and calculated the change that occurred between these two time-points (ΔIGF-I). Patients (N = 380; 63.4% males; mean age, 54.7 years) with data on 1-year leisure-time pre-stroke PA and post-stroke s-IGF-I levels were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Pre-stroke, leisure-time PA was self-reported as PA1–4, with PA1 representing sedentary and PA2–4 indicating progressively higher PA levels. Associations between s-IGF-I and PA were evaluated by multiple linear regressions with PA1 as the reference and adjustments being made for sex, age, history of previous stroke or myocardial infarctions, cardiovascular risk factors, and stroke severity. PA correlated with baseline s-IGF-I and ΔIGF-I, but not with the 3-month s-IGF-I. In the linear regressions, there were corresponding associations that remained as a tendency (baseline s-IGF-I, p = 0.06) or as a significant effect (ΔIGF-I, p = 0.03) after all the adjustments. Specifically, for each unit of PA, ΔIGF-I increased by 9.7 (95% CI 1,1−18.4) ng/mL after full adjustment. This supports the notion that pre-stroke PA is independently related to ΔIGF-I.
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spelling pubmed-71485082020-04-20 Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I Åberg, N. David Gadd, Gustaf Åberg, Daniel Hällgren, Peter Blomstrand, Christian Jood, Katarina Nilsson, Michael Walker, Fredrick R. Svensson, Johan Jern, Christina Isgaard, Jörgen Biomedicines Article Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail. We investigated the pre-stroke PA level in relation to the post-stroke serum IGF-I (s-IGF-I) level, at baseline and at 3 months after the index stroke, and calculated the change that occurred between these two time-points (ΔIGF-I). Patients (N = 380; 63.4% males; mean age, 54.7 years) with data on 1-year leisure-time pre-stroke PA and post-stroke s-IGF-I levels were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Pre-stroke, leisure-time PA was self-reported as PA1–4, with PA1 representing sedentary and PA2–4 indicating progressively higher PA levels. Associations between s-IGF-I and PA were evaluated by multiple linear regressions with PA1 as the reference and adjustments being made for sex, age, history of previous stroke or myocardial infarctions, cardiovascular risk factors, and stroke severity. PA correlated with baseline s-IGF-I and ΔIGF-I, but not with the 3-month s-IGF-I. In the linear regressions, there were corresponding associations that remained as a tendency (baseline s-IGF-I, p = 0.06) or as a significant effect (ΔIGF-I, p = 0.03) after all the adjustments. Specifically, for each unit of PA, ΔIGF-I increased by 9.7 (95% CI 1,1−18.4) ng/mL after full adjustment. This supports the notion that pre-stroke PA is independently related to ΔIGF-I. MDPI 2020-03-04 /pmc/articles/PMC7148508/ /pubmed/32143318 http://dx.doi.org/10.3390/biomedicines8030052 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Åberg, N. David
Gadd, Gustaf
Åberg, Daniel
Hällgren, Peter
Blomstrand, Christian
Jood, Katarina
Nilsson, Michael
Walker, Fredrick R.
Svensson, Johan
Jern, Christina
Isgaard, Jörgen
Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title_full Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title_fullStr Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title_full_unstemmed Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title_short Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I
title_sort relationship between levels of pre-stroke physical activity and post-stroke serum insulin-like growth factor i
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148508/
https://www.ncbi.nlm.nih.gov/pubmed/32143318
http://dx.doi.org/10.3390/biomedicines8030052
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