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Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optica...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148510/ https://www.ncbi.nlm.nih.gov/pubmed/32143497 http://dx.doi.org/10.3390/biomedicines8030054 |
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author | Casado, Alfonso López-de-Eguileta, Alicia Fonseca, Soraya Muñoz, Pedro Demetrio, Rosalía Gordo-Vega, Miguel A. Cerveró, Andrea |
author_facet | Casado, Alfonso López-de-Eguileta, Alicia Fonseca, Soraya Muñoz, Pedro Demetrio, Rosalía Gordo-Vega, Miguel A. Cerveró, Andrea |
author_sort | Casado, Alfonso |
collection | PubMed |
description | In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optical coherence tomography (OCT) in the early diagnosis of retinopathy. One hundred and fourteen eyes of 76 individuals with HCQ treatment were enrolled in the study (42 eyes with impaired visual field (VF) and 72 eyes with nondamaged VF). We found that ONL was significantly decreased in the HCQ retinopathy group compared with the control group in the nasal macula (p = 0.032) as well as in four sectors (p < 0.044), whereas no significant differences were found comparing GCL in both groups. If VF were altered superiorly or temporarily, ONL was significantly thinned inferiorly (p = 0.029) and nasally (p = 0.008), respectively. Duration of HCQ treatment was significantly related with ONL in seven sectors of ONL (p < 0.047). We suggest that ONL measured with OCT might be used to assess early HCQ retinal toxicity. |
format | Online Article Text |
id | pubmed-7148510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71485102020-04-20 Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine Casado, Alfonso López-de-Eguileta, Alicia Fonseca, Soraya Muñoz, Pedro Demetrio, Rosalía Gordo-Vega, Miguel A. Cerveró, Andrea Biomedicines Article In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optical coherence tomography (OCT) in the early diagnosis of retinopathy. One hundred and fourteen eyes of 76 individuals with HCQ treatment were enrolled in the study (42 eyes with impaired visual field (VF) and 72 eyes with nondamaged VF). We found that ONL was significantly decreased in the HCQ retinopathy group compared with the control group in the nasal macula (p = 0.032) as well as in four sectors (p < 0.044), whereas no significant differences were found comparing GCL in both groups. If VF were altered superiorly or temporarily, ONL was significantly thinned inferiorly (p = 0.029) and nasally (p = 0.008), respectively. Duration of HCQ treatment was significantly related with ONL in seven sectors of ONL (p < 0.047). We suggest that ONL measured with OCT might be used to assess early HCQ retinal toxicity. MDPI 2020-03-04 /pmc/articles/PMC7148510/ /pubmed/32143497 http://dx.doi.org/10.3390/biomedicines8030054 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Casado, Alfonso López-de-Eguileta, Alicia Fonseca, Soraya Muñoz, Pedro Demetrio, Rosalía Gordo-Vega, Miguel A. Cerveró, Andrea Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title | Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title_full | Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title_fullStr | Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title_full_unstemmed | Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title_short | Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine |
title_sort | outer nuclear layer damage for detection of early retinal toxicity of hydroxychloroquine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148510/ https://www.ncbi.nlm.nih.gov/pubmed/32143497 http://dx.doi.org/10.3390/biomedicines8030054 |
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