Cargando…

Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine

In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optica...

Descripción completa

Detalles Bibliográficos
Autores principales: Casado, Alfonso, López-de-Eguileta, Alicia, Fonseca, Soraya, Muñoz, Pedro, Demetrio, Rosalía, Gordo-Vega, Miguel A., Cerveró, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148510/
https://www.ncbi.nlm.nih.gov/pubmed/32143497
http://dx.doi.org/10.3390/biomedicines8030054
_version_ 1783520609279410176
author Casado, Alfonso
López-de-Eguileta, Alicia
Fonseca, Soraya
Muñoz, Pedro
Demetrio, Rosalía
Gordo-Vega, Miguel A.
Cerveró, Andrea
author_facet Casado, Alfonso
López-de-Eguileta, Alicia
Fonseca, Soraya
Muñoz, Pedro
Demetrio, Rosalía
Gordo-Vega, Miguel A.
Cerveró, Andrea
author_sort Casado, Alfonso
collection PubMed
description In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optical coherence tomography (OCT) in the early diagnosis of retinopathy. One hundred and fourteen eyes of 76 individuals with HCQ treatment were enrolled in the study (42 eyes with impaired visual field (VF) and 72 eyes with nondamaged VF). We found that ONL was significantly decreased in the HCQ retinopathy group compared with the control group in the nasal macula (p = 0.032) as well as in four sectors (p < 0.044), whereas no significant differences were found comparing GCL in both groups. If VF were altered superiorly or temporarily, ONL was significantly thinned inferiorly (p = 0.029) and nasally (p = 0.008), respectively. Duration of HCQ treatment was significantly related with ONL in seven sectors of ONL (p < 0.047). We suggest that ONL measured with OCT might be used to assess early HCQ retinal toxicity.
format Online
Article
Text
id pubmed-7148510
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71485102020-04-20 Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine Casado, Alfonso López-de-Eguileta, Alicia Fonseca, Soraya Muñoz, Pedro Demetrio, Rosalía Gordo-Vega, Miguel A. Cerveró, Andrea Biomedicines Article In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion cell layer (GCL) and outer nuclear layer (ONL) thicknesses measured by optical coherence tomography (OCT) in the early diagnosis of retinopathy. One hundred and fourteen eyes of 76 individuals with HCQ treatment were enrolled in the study (42 eyes with impaired visual field (VF) and 72 eyes with nondamaged VF). We found that ONL was significantly decreased in the HCQ retinopathy group compared with the control group in the nasal macula (p = 0.032) as well as in four sectors (p < 0.044), whereas no significant differences were found comparing GCL in both groups. If VF were altered superiorly or temporarily, ONL was significantly thinned inferiorly (p = 0.029) and nasally (p = 0.008), respectively. Duration of HCQ treatment was significantly related with ONL in seven sectors of ONL (p < 0.047). We suggest that ONL measured with OCT might be used to assess early HCQ retinal toxicity. MDPI 2020-03-04 /pmc/articles/PMC7148510/ /pubmed/32143497 http://dx.doi.org/10.3390/biomedicines8030054 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Casado, Alfonso
López-de-Eguileta, Alicia
Fonseca, Soraya
Muñoz, Pedro
Demetrio, Rosalía
Gordo-Vega, Miguel A.
Cerveró, Andrea
Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title_full Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title_fullStr Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title_full_unstemmed Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title_short Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine
title_sort outer nuclear layer damage for detection of early retinal toxicity of hydroxychloroquine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148510/
https://www.ncbi.nlm.nih.gov/pubmed/32143497
http://dx.doi.org/10.3390/biomedicines8030054
work_keys_str_mv AT casadoalfonso outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT lopezdeeguiletaalicia outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT fonsecasoraya outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT munozpedro outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT demetriorosalia outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT gordovegamiguela outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine
AT cerveroandrea outernuclearlayerdamagefordetectionofearlyretinaltoxicityofhydroxychloroquine