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Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are cri...

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Autores principales: Ross, Colton J., Zheng, Junnan, Ma, Liang, Wu, Yi, Lee, Chung-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148526/
https://www.ncbi.nlm.nih.gov/pubmed/32178262
http://dx.doi.org/10.3390/bioengineering7010025
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author Ross, Colton J.
Zheng, Junnan
Ma, Liang
Wu, Yi
Lee, Chung-Hao
author_facet Ross, Colton J.
Zheng, Junnan
Ma, Liang
Wu, Yi
Lee, Chung-Hao
author_sort Ross, Colton J.
collection PubMed
description The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers have sought to better understand the mechanics and microstructure of the chordae tendineae of the AHVs. The intricate structures of the chordae tendineae have become of increasing interest in recent literature, and there are several key findings that have not been comprehensively summarized in one review. Therefore, in this review paper, we will provide a summary of the current state of biomechanical and microstructural characterizations of the chordae tendineae, and also discuss perspectives for future studies that will aid in a better understanding of the tissue mechanics–microstructure linking of the AHVs’ chordae tendineae, and thereby improve the therapeutics for heart valve diseases caused by chordae failures.
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spelling pubmed-71485262020-04-20 Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review Ross, Colton J. Zheng, Junnan Ma, Liang Wu, Yi Lee, Chung-Hao Bioengineering (Basel) Review The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers have sought to better understand the mechanics and microstructure of the chordae tendineae of the AHVs. The intricate structures of the chordae tendineae have become of increasing interest in recent literature, and there are several key findings that have not been comprehensively summarized in one review. Therefore, in this review paper, we will provide a summary of the current state of biomechanical and microstructural characterizations of the chordae tendineae, and also discuss perspectives for future studies that will aid in a better understanding of the tissue mechanics–microstructure linking of the AHVs’ chordae tendineae, and thereby improve the therapeutics for heart valve diseases caused by chordae failures. MDPI 2020-03-12 /pmc/articles/PMC7148526/ /pubmed/32178262 http://dx.doi.org/10.3390/bioengineering7010025 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ross, Colton J.
Zheng, Junnan
Ma, Liang
Wu, Yi
Lee, Chung-Hao
Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title_full Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title_fullStr Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title_full_unstemmed Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title_short Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
title_sort mechanics and microstructure of the atrioventricular heart valve chordae tendineae: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148526/
https://www.ncbi.nlm.nih.gov/pubmed/32178262
http://dx.doi.org/10.3390/bioengineering7010025
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