Cargando…
Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specifi...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Medical Association Publishing House. Published by Elsevier B.V.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148670/ https://www.ncbi.nlm.nih.gov/pubmed/32501444 http://dx.doi.org/10.1016/j.bsheal.2019.10.004 |
_version_ | 1783520641513684992 |
---|---|
author | Li, Hongying Mendelsohn, Emma Zong, Chen Zhang, Wei Hagan, Emily Wang, Ning Li, Shiyue Yan, Hong Huang, Huimin Zhu, Guangjian Ross, Noam Chmura, Aleksei Terry, Philip Fielder, Mark Miller, Maureen Shi, Zhengli Daszak, Peter |
author_facet | Li, Hongying Mendelsohn, Emma Zong, Chen Zhang, Wei Hagan, Emily Wang, Ning Li, Shiyue Yan, Hong Huang, Huimin Zhu, Guangjian Ross, Noam Chmura, Aleksei Terry, Philip Fielder, Mark Miller, Maureen Shi, Zhengli Daszak, Peter |
author_sort | Li, Hongying |
collection | PubMed |
description | Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence. |
format | Online Article Text |
id | pubmed-7148670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Chinese Medical Association Publishing House. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71486702020-04-13 Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China Li, Hongying Mendelsohn, Emma Zong, Chen Zhang, Wei Hagan, Emily Wang, Ning Li, Shiyue Yan, Hong Huang, Huimin Zhu, Guangjian Ross, Noam Chmura, Aleksei Terry, Philip Fielder, Mark Miller, Maureen Shi, Zhengli Daszak, Peter Biosaf Health Article Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence. Chinese Medical Association Publishing House. Published by Elsevier B.V. 2019-09 2019-11-09 /pmc/articles/PMC7148670/ /pubmed/32501444 http://dx.doi.org/10.1016/j.bsheal.2019.10.004 Text en © 2019 Chinese Medical Association Publishing House. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Li, Hongying Mendelsohn, Emma Zong, Chen Zhang, Wei Hagan, Emily Wang, Ning Li, Shiyue Yan, Hong Huang, Huimin Zhu, Guangjian Ross, Noam Chmura, Aleksei Terry, Philip Fielder, Mark Miller, Maureen Shi, Zhengli Daszak, Peter Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title_full | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title_fullStr | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title_full_unstemmed | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title_short | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China |
title_sort | human-animal interactions and bat coronavirus spillover potential among rural residents in southern china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148670/ https://www.ncbi.nlm.nih.gov/pubmed/32501444 http://dx.doi.org/10.1016/j.bsheal.2019.10.004 |
work_keys_str_mv | AT lihongying humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT mendelsohnemma humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT zongchen humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT zhangwei humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT haganemily humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT wangning humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT lishiyue humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT yanhong humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT huanghuimin humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT zhuguangjian humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT rossnoam humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT chmuraaleksei humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT terryphilip humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT fieldermark humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT millermaureen humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT shizhengli humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina AT daszakpeter humananimalinteractionsandbatcoronavirusspilloverpotentialamongruralresidentsinsouthernchina |