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Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specifi...

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Autores principales: Li, Hongying, Mendelsohn, Emma, Zong, Chen, Zhang, Wei, Hagan, Emily, Wang, Ning, Li, Shiyue, Yan, Hong, Huang, Huimin, Zhu, Guangjian, Ross, Noam, Chmura, Aleksei, Terry, Philip, Fielder, Mark, Miller, Maureen, Shi, Zhengli, Daszak, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Medical Association Publishing House. Published by Elsevier B.V. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148670/
https://www.ncbi.nlm.nih.gov/pubmed/32501444
http://dx.doi.org/10.1016/j.bsheal.2019.10.004
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author Li, Hongying
Mendelsohn, Emma
Zong, Chen
Zhang, Wei
Hagan, Emily
Wang, Ning
Li, Shiyue
Yan, Hong
Huang, Huimin
Zhu, Guangjian
Ross, Noam
Chmura, Aleksei
Terry, Philip
Fielder, Mark
Miller, Maureen
Shi, Zhengli
Daszak, Peter
author_facet Li, Hongying
Mendelsohn, Emma
Zong, Chen
Zhang, Wei
Hagan, Emily
Wang, Ning
Li, Shiyue
Yan, Hong
Huang, Huimin
Zhu, Guangjian
Ross, Noam
Chmura, Aleksei
Terry, Philip
Fielder, Mark
Miller, Maureen
Shi, Zhengli
Daszak, Peter
author_sort Li, Hongying
collection PubMed
description Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.
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spelling pubmed-71486702020-04-13 Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China Li, Hongying Mendelsohn, Emma Zong, Chen Zhang, Wei Hagan, Emily Wang, Ning Li, Shiyue Yan, Hong Huang, Huimin Zhu, Guangjian Ross, Noam Chmura, Aleksei Terry, Philip Fielder, Mark Miller, Maureen Shi, Zhengli Daszak, Peter Biosaf Health Article Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence. Chinese Medical Association Publishing House. Published by Elsevier B.V. 2019-09 2019-11-09 /pmc/articles/PMC7148670/ /pubmed/32501444 http://dx.doi.org/10.1016/j.bsheal.2019.10.004 Text en © 2019 Chinese Medical Association Publishing House. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Hongying
Mendelsohn, Emma
Zong, Chen
Zhang, Wei
Hagan, Emily
Wang, Ning
Li, Shiyue
Yan, Hong
Huang, Huimin
Zhu, Guangjian
Ross, Noam
Chmura, Aleksei
Terry, Philip
Fielder, Mark
Miller, Maureen
Shi, Zhengli
Daszak, Peter
Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title_full Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title_fullStr Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title_full_unstemmed Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title_short Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
title_sort human-animal interactions and bat coronavirus spillover potential among rural residents in southern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148670/
https://www.ncbi.nlm.nih.gov/pubmed/32501444
http://dx.doi.org/10.1016/j.bsheal.2019.10.004
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