A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation

A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoumarin 6 employing an appropriate solvent of CS(2)–PhNO...

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Detalles Bibliográficos
Autores principales: Chopade, Anil U., Chopade, Manojkumar U., Chanda, Bhanu M., Sawaikar, Dilip D., Sonawane, Kiran B., Gurjar, Mukund K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Production and hosting by Elsevier B.V. on behalf of King Saud University. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148711/
http://dx.doi.org/10.1016/j.arabjc.2012.04.027

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