Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation

The capability of arbidol microparticle preparation by supercritical antisolvent (SAS) precipitation was demonstrated. A nonmonotonic dependence of the average particle size on the concentration was found, while the position of the minimum is dependent on the type of solvent used. It is possible to...

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Detalles Bibliográficos
Autores principales: Vorobei, A. M., Pokrovskiy, O. I., Ustinovich, K. B., Krotova, L. I., Parenago, O. O., Lunin, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149032/
http://dx.doi.org/10.1134/S1990793116070198
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author Vorobei, A. M.
Pokrovskiy, O. I.
Ustinovich, K. B.
Krotova, L. I.
Parenago, O. O.
Lunin, V. V.
author_facet Vorobei, A. M.
Pokrovskiy, O. I.
Ustinovich, K. B.
Krotova, L. I.
Parenago, O. O.
Lunin, V. V.
author_sort Vorobei, A. M.
collection PubMed
description The capability of arbidol microparticle preparation by supercritical antisolvent (SAS) precipitation was demonstrated. A nonmonotonic dependence of the average particle size on the concentration was found, while the position of the minimum is dependent on the type of solvent used. It is possible to prepare Arbidol particles of various morphology and size from several microns to several hundred microns depending on the conditions.
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spelling pubmed-71490322020-04-13 Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation Vorobei, A. M. Pokrovskiy, O. I. Ustinovich, K. B. Krotova, L. I. Parenago, O. O. Lunin, V. V. Russian Journal of Physical Chemistry B Article The capability of arbidol microparticle preparation by supercritical antisolvent (SAS) precipitation was demonstrated. A nonmonotonic dependence of the average particle size on the concentration was found, while the position of the minimum is dependent on the type of solvent used. It is possible to prepare Arbidol particles of various morphology and size from several microns to several hundred microns depending on the conditions. Pleiades Publishing 2017-02-11 2016 /pmc/articles/PMC7149032/ http://dx.doi.org/10.1134/S1990793116070198 Text en © Pleiades Publishing, Ltd. 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Vorobei, A. M.
Pokrovskiy, O. I.
Ustinovich, K. B.
Krotova, L. I.
Parenago, O. O.
Lunin, V. V.
Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title_full Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title_fullStr Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title_full_unstemmed Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title_short Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
title_sort effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149032/
http://dx.doi.org/10.1134/S1990793116070198
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