microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines

MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years,...

Descripción completa

Detalles Bibliográficos
Autores principales: Leon-Icaza, Stephen A., Zeng, Mingtao, Rosas-Taraco, Adrian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149109/
https://www.ncbi.nlm.nih.gov/pubmed/34171007
http://dx.doi.org/10.1186/s41544-018-0004-7
_version_ 1783520739407691776
author Leon-Icaza, Stephen A.
Zeng, Mingtao
Rosas-Taraco, Adrian G.
author_facet Leon-Icaza, Stephen A.
Zeng, Mingtao
Rosas-Taraco, Adrian G.
author_sort Leon-Icaza, Stephen A.
collection PubMed
description MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development.
format Online
Article
Text
id pubmed-7149109
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-71491092020-04-13 microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines Leon-Icaza, Stephen A. Zeng, Mingtao Rosas-Taraco, Adrian G. ExRNA Review MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development. BioMed Central 2019-02-14 2019 /pmc/articles/PMC7149109/ /pubmed/34171007 http://dx.doi.org/10.1186/s41544-018-0004-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Leon-Icaza, Stephen A.
Zeng, Mingtao
Rosas-Taraco, Adrian G.
microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title_full microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title_fullStr microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title_full_unstemmed microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title_short microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
title_sort micrornas in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149109/
https://www.ncbi.nlm.nih.gov/pubmed/34171007
http://dx.doi.org/10.1186/s41544-018-0004-7
work_keys_str_mv AT leonicazastephena micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines
AT zengmingtao micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines
AT rosastaracoadriang micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines

Ejemplares similares