Molecular Pathology and Infectious Diseases

This chapter discusses the pathogenesis and progression of infectious diseases. Agricultural and industrial development has resulted in the increased density of humans living in close proximity to each other. This lifestyle change from more rural existence has brought humans in closer proximity to wild animals that harbor potential future human pathogens. Most diseases are transmitted by insect vectors. Molecular diagnostic tests can be divided into two primary groups. The first are tests designed to detect the presence of mutations in the human genome that are associated with specific diseases. These tests need to be performed only once in a specific individual’s lifetime. The second group of molecular diagnostic assays is designed to detect infectious agents or the recurrence of a mutation specifically associated with a tumor the patient has had in the past. Bacterial, viral, fungal, or parasitic infections can be eradicated and recur at a time in the future requiring repetition of the same molecular assay for detection. Minimal residual disease detection refers to the analysis of tissue/cells in a patient previously diagnosed with a malignancy to evaluate if therapy was completed successfully or if rare malignant cells are present.