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Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients

AIM: To assess the immunological reactions and gene expression level in the celiac disease (CD) patients under a gluten-free diet (GFD). BACKGROUND: CD is an autoimmune disorder in genetic susceptible individuals and lifelong gluten free diet is the effective treatment method. It seems that treated...

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Autores principales: Rostami-Nejad, Mohammad, Razzaghi, Zahra, Esmaeili, Somayeh, Rezaei-Tavirani, Sina, Akbarzadeh Baghban, Alireza, Vafaee, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149810/
https://www.ncbi.nlm.nih.gov/pubmed/32308937
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author Rostami-Nejad, Mohammad
Razzaghi, Zahra
Esmaeili, Somayeh
Rezaei-Tavirani, Sina
Akbarzadeh Baghban, Alireza
Vafaee, Reza
author_facet Rostami-Nejad, Mohammad
Razzaghi, Zahra
Esmaeili, Somayeh
Rezaei-Tavirani, Sina
Akbarzadeh Baghban, Alireza
Vafaee, Reza
author_sort Rostami-Nejad, Mohammad
collection PubMed
description AIM: To assess the immunological reactions and gene expression level in the celiac disease (CD) patients under a gluten-free diet (GFD). BACKGROUND: CD is an autoimmune disorder in genetic susceptible individuals and lifelong gluten free diet is the effective treatment method. It seems that treated patients will experience a normal life style though there are documents about some potential damages. METHODS: Gene expression profiles of treated CD patients and healthy samples were obtained from Gene Expression Omnibus (GEO) and compared to find the differentially expressed genes (DEGs). The identified DEGs were introduced in the network and gene ontology (GO) analysis. RESULTS: Ten differentially expressed genes (DEGs) including CCR2, IRF4, FASLG, CCR4, ICOS, TNFSF18, BACH2, LTF, PRM1, and PRM2 were investigated via network analysis. Seven clusters of biological processes (BP) were determined as the affected BP. PThe finding led to introduction of CCR2, IRF4, FASLG, CCR4, and ICOS as the potential immunological markers that are still active despite GFD in the treated CD patients. CONCLUSION: The results of this study indicated that the immune system is already active in treated CD patients despite GFD treatment and exposure to gluten causes potential immunological reactions in these patients.
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spelling pubmed-71498102020-04-17 Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients Rostami-Nejad, Mohammad Razzaghi, Zahra Esmaeili, Somayeh Rezaei-Tavirani, Sina Akbarzadeh Baghban, Alireza Vafaee, Reza Gastroenterol Hepatol Bed Bench Original Article AIM: To assess the immunological reactions and gene expression level in the celiac disease (CD) patients under a gluten-free diet (GFD). BACKGROUND: CD is an autoimmune disorder in genetic susceptible individuals and lifelong gluten free diet is the effective treatment method. It seems that treated patients will experience a normal life style though there are documents about some potential damages. METHODS: Gene expression profiles of treated CD patients and healthy samples were obtained from Gene Expression Omnibus (GEO) and compared to find the differentially expressed genes (DEGs). The identified DEGs were introduced in the network and gene ontology (GO) analysis. RESULTS: Ten differentially expressed genes (DEGs) including CCR2, IRF4, FASLG, CCR4, ICOS, TNFSF18, BACH2, LTF, PRM1, and PRM2 were investigated via network analysis. Seven clusters of biological processes (BP) were determined as the affected BP. PThe finding led to introduction of CCR2, IRF4, FASLG, CCR4, and ICOS as the potential immunological markers that are still active despite GFD in the treated CD patients. CONCLUSION: The results of this study indicated that the immune system is already active in treated CD patients despite GFD treatment and exposure to gluten causes potential immunological reactions in these patients. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7149810/ /pubmed/32308937 Text en ©2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rostami-Nejad, Mohammad
Razzaghi, Zahra
Esmaeili, Somayeh
Rezaei-Tavirani, Sina
Akbarzadeh Baghban, Alireza
Vafaee, Reza
Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title_full Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title_fullStr Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title_full_unstemmed Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title_short Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients
title_sort immunological reactions by t cell and regulation of crucial genes in treated celiac disease patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149810/
https://www.ncbi.nlm.nih.gov/pubmed/32308937
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