Cargando…
Control of gene expression by translational recoding
Like all rules, even the genetic code has exceptions: these are generically classified as “translational recoding.” Almost every conceivable mode of recoding has been documented, including signals that redefine translational reading frame and codon assignation. While first described in viruses, it i...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149833/ https://www.ncbi.nlm.nih.gov/pubmed/22243583 http://dx.doi.org/10.1016/B978-0-12-386497-0.00004-9 |
_version_ | 1783520893855596544 |
---|---|
author | Dinman, Jonathan D. |
author_facet | Dinman, Jonathan D. |
author_sort | Dinman, Jonathan D. |
collection | PubMed |
description | Like all rules, even the genetic code has exceptions: these are generically classified as “translational recoding.” Almost every conceivable mode of recoding has been documented, including signals that redefine translational reading frame and codon assignation. While first described in viruses, it is becoming clear that sequences that program elongating ribosomes to shift translational reading frame are widely used by organisms in all domains of life, thus expanding both the coding capacity of genomes and the modes through which gene expression can be regulated at the posttranscriptional level. Instances of programmed ribosomal frameshifting and stop codon reassignment are opening up new avenues for treatment of numerous inborn errors of metabolism. The implications of these findings on human health are only beginning to emerge. |
format | Online Article Text |
id | pubmed-7149833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71498332020-04-13 Control of gene expression by translational recoding Dinman, Jonathan D. Adv Protein Chem Struct Biol Article Like all rules, even the genetic code has exceptions: these are generically classified as “translational recoding.” Almost every conceivable mode of recoding has been documented, including signals that redefine translational reading frame and codon assignation. While first described in viruses, it is becoming clear that sequences that program elongating ribosomes to shift translational reading frame are widely used by organisms in all domains of life, thus expanding both the coding capacity of genomes and the modes through which gene expression can be regulated at the posttranscriptional level. Instances of programmed ribosomal frameshifting and stop codon reassignment are opening up new avenues for treatment of numerous inborn errors of metabolism. The implications of these findings on human health are only beginning to emerge. Elsevier Inc. 2012 2012-01-12 /pmc/articles/PMC7149833/ /pubmed/22243583 http://dx.doi.org/10.1016/B978-0-12-386497-0.00004-9 Text en Copyright © 2012 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Dinman, Jonathan D. Control of gene expression by translational recoding |
title | Control of gene expression by translational recoding |
title_full | Control of gene expression by translational recoding |
title_fullStr | Control of gene expression by translational recoding |
title_full_unstemmed | Control of gene expression by translational recoding |
title_short | Control of gene expression by translational recoding |
title_sort | control of gene expression by translational recoding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149833/ https://www.ncbi.nlm.nih.gov/pubmed/22243583 http://dx.doi.org/10.1016/B978-0-12-386497-0.00004-9 |
work_keys_str_mv | AT dinmanjonathand controlofgeneexpressionbytranslationalrecoding |