Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats

OBJECTIVE: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of  green coffee extract on body weight, serum lipids, and TNF-α level in high-fa...

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Autores principales: Ilmiawati, Cimi, Fitri, Fajar, Rofinda, Zelly Dia, Reza, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149906/
https://www.ncbi.nlm.nih.gov/pubmed/32276657
http://dx.doi.org/10.1186/s13104-020-05052-y
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author Ilmiawati, Cimi
Fitri, Fajar
Rofinda, Zelly Dia
Reza, Mohamad
author_facet Ilmiawati, Cimi
Fitri, Fajar
Rofinda, Zelly Dia
Reza, Mohamad
author_sort Ilmiawati, Cimi
collection PubMed
description OBJECTIVE: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of  green coffee extract on body weight, serum lipids, and TNF-α level in high-fat diet-induced obese rats. RESULTS: Administration of green coffee extract to high-fat diet-induced obese male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered serum LDL-cholesterol at the treatment dose of 20 mg/kg BW/day (p < 0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results support the potential use of green coffee extract as a functional nutrient in the management of obesity.
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spelling pubmed-71499062020-04-19 Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats Ilmiawati, Cimi Fitri, Fajar Rofinda, Zelly Dia Reza, Mohamad BMC Res Notes Research Note OBJECTIVE: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of  green coffee extract on body weight, serum lipids, and TNF-α level in high-fat diet-induced obese rats. RESULTS: Administration of green coffee extract to high-fat diet-induced obese male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered serum LDL-cholesterol at the treatment dose of 20 mg/kg BW/day (p < 0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results support the potential use of green coffee extract as a functional nutrient in the management of obesity. BioMed Central 2020-04-10 /pmc/articles/PMC7149906/ /pubmed/32276657 http://dx.doi.org/10.1186/s13104-020-05052-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Ilmiawati, Cimi
Fitri, Fajar
Rofinda, Zelly Dia
Reza, Mohamad
Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title_full Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title_fullStr Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title_full_unstemmed Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title_short Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats
title_sort green coffee extract modifies body weight, serum lipids and tnf-α in high-fat diet-induced obese rats
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149906/
https://www.ncbi.nlm.nih.gov/pubmed/32276657
http://dx.doi.org/10.1186/s13104-020-05052-y
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