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HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis

As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoprotein...

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Detalles Bibliográficos
Autores principales: Dunn, Ewan F., Connor, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149925/
https://www.ncbi.nlm.nih.gov/pubmed/22340720
http://dx.doi.org/10.1016/B978-0-12-396456-4.00002-X
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author Dunn, Ewan F.
Connor, John H.
author_facet Dunn, Ewan F.
Connor, John H.
author_sort Dunn, Ewan F.
collection PubMed
description As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to promote a variety of viral processes, from control of entry to nuclear function to the stimulation of viral protein synthesis. This review focuses on the takeover of the cellular phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway by a variety of retroviruses, DNA viruses, and RNA viruses, highlighting the functions ascribed to virus activation of PI3K and Akt activity. This review also describes the role that the PI3K/Akt pathway plays in the host response, noting that it that can trigger anti- as well as proviral functions.
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spelling pubmed-71499252020-04-13 HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis Dunn, Ewan F. Connor, John H. Prog Mol Biol Transl Sci Article As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to promote a variety of viral processes, from control of entry to nuclear function to the stimulation of viral protein synthesis. This review focuses on the takeover of the cellular phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway by a variety of retroviruses, DNA viruses, and RNA viruses, highlighting the functions ascribed to virus activation of PI3K and Akt activity. This review also describes the role that the PI3K/Akt pathway plays in the host response, noting that it that can trigger anti- as well as proviral functions. Elsevier Inc. 2012 2012-02-13 /pmc/articles/PMC7149925/ /pubmed/22340720 http://dx.doi.org/10.1016/B978-0-12-396456-4.00002-X Text en Copyright © 2012 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Dunn, Ewan F.
Connor, John H.
HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title_full HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title_fullStr HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title_full_unstemmed HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title_short HijAkt: The PI3K/Akt Pathway in Virus Replication and Pathogenesis
title_sort hijakt: the pi3k/akt pathway in virus replication and pathogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149925/
https://www.ncbi.nlm.nih.gov/pubmed/22340720
http://dx.doi.org/10.1016/B978-0-12-396456-4.00002-X
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