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Quasispecies Dynamics in Disease Prevention and Control

Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host, as well as those that expand at the epidemiological level. Strategies intended to minimize vaccination and treatmen...

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Detalles Bibliográficos
Autor principal: Domingo, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149962/
http://dx.doi.org/10.1016/B978-0-12-800837-9.00008-3
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author Domingo, Esteban
author_facet Domingo, Esteban
author_sort Domingo, Esteban
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description Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host, as well as those that expand at the epidemiological level. Strategies intended to minimize vaccination and treatment failures are proposed, and justified based on fundamental features of viral dynamics. The recommended use of complex, multiepitopic vaccines and combination therapies as early as possible after initiation of an infection falls under the general concept that complexity cannot be combated with simplicity. It follows also that socio-political action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale.
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spelling pubmed-71499622020-04-13 Quasispecies Dynamics in Disease Prevention and Control Domingo, Esteban Virus as Populations Article Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host, as well as those that expand at the epidemiological level. Strategies intended to minimize vaccination and treatment failures are proposed, and justified based on fundamental features of viral dynamics. The recommended use of complex, multiepitopic vaccines and combination therapies as early as possible after initiation of an infection falls under the general concept that complexity cannot be combated with simplicity. It follows also that socio-political action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale. 2016 2015-10-01 /pmc/articles/PMC7149962/ http://dx.doi.org/10.1016/B978-0-12-800837-9.00008-3 Text en Copyright © 2016 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Domingo, Esteban
Quasispecies Dynamics in Disease Prevention and Control
title Quasispecies Dynamics in Disease Prevention and Control
title_full Quasispecies Dynamics in Disease Prevention and Control
title_fullStr Quasispecies Dynamics in Disease Prevention and Control
title_full_unstemmed Quasispecies Dynamics in Disease Prevention and Control
title_short Quasispecies Dynamics in Disease Prevention and Control
title_sort quasispecies dynamics in disease prevention and control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149962/
http://dx.doi.org/10.1016/B978-0-12-800837-9.00008-3
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