Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus

The intermediate compartment (IC) is a pleiomorphic membrane system that mediates two-way trafficing in the early biosynthetic-secretory pathway of mammalian cells. The IC associates with the cytoskeleton, binds COPI (coat protein I) coats and generates vesicular, tubular and saccular transport carr...

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Detalles Bibliográficos
Autores principales: Saraste, J., Marie, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150006/
http://dx.doi.org/10.1016/B978-0-12-394447-4.20013-8
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author Saraste, J.
Marie, M.
author_facet Saraste, J.
Marie, M.
author_sort Saraste, J.
collection PubMed
description The intermediate compartment (IC) is a pleiomorphic membrane system that mediates two-way trafficing in the early biosynthetic-secretory pathway of mammalian cells. The IC associates with the cytoskeleton, binds COPI (coat protein I) coats and generates vesicular, tubular and saccular transport carriers. It recieves newly made proteins and lipids from the endoplasmic reticulum (ER) and sorts them for transport to the Golgi apparatus or recycling back to the ER. Although the IC appears to be functionally complex and resides at the crossroads of multiple transport routes, it is still disputed whether it represents a transient or stable structure.
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spelling pubmed-71500062020-04-13 Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus Saraste, J. Marie, M. Encyclopedia of Cell Biology Article The intermediate compartment (IC) is a pleiomorphic membrane system that mediates two-way trafficing in the early biosynthetic-secretory pathway of mammalian cells. The IC associates with the cytoskeleton, binds COPI (coat protein I) coats and generates vesicular, tubular and saccular transport carriers. It recieves newly made proteins and lipids from the endoplasmic reticulum (ER) and sorts them for transport to the Golgi apparatus or recycling back to the ER. Although the IC appears to be functionally complex and resides at the crossroads of multiple transport routes, it is still disputed whether it represents a transient or stable structure. 2016 2015-08-20 /pmc/articles/PMC7150006/ http://dx.doi.org/10.1016/B978-0-12-394447-4.20013-8 Text en Copyright © 2016 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Saraste, J.
Marie, M.
Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title_full Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title_fullStr Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title_full_unstemmed Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title_short Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
title_sort intermediate compartment: a sorting station between the endoplasmic reticulum and the golgi apparatus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150006/
http://dx.doi.org/10.1016/B978-0-12-394447-4.20013-8
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