Breakdown of the Blood–Retinal Barrier

Macular edema that results from blood–retinal barrier (BRB) breakdown is a cause of significant visual loss associated with a variety of ocular disorders. BRB breakdown is a complex process that is regulated by multiple factors and involves different mechanisms. A variety of therapeutic approaches h...

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Detalles Bibliográficos
Autor principal: Vinores, S.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150236/
http://dx.doi.org/10.1016/B978-0-12-374203-2.00137-8
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author Vinores, S.A.
author_facet Vinores, S.A.
author_sort Vinores, S.A.
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description Macular edema that results from blood–retinal barrier (BRB) breakdown is a cause of significant visual loss associated with a variety of ocular disorders. BRB breakdown is a complex process that is regulated by multiple factors and involves different mechanisms. A variety of therapeutic approaches have shown modest suppression of macular edema, but to obtain greater efficacy, it is likely that multiple molecules, operating through distinct mechanisms, may need to be targeted. Studies aimed at identifying key target molecules and the optimal strategies for inhibiting them are ongoing in several laboratories.
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spelling pubmed-71502362020-04-13 Breakdown of the Blood–Retinal Barrier Vinores, S.A. Encyclopedia of the Eye Article Macular edema that results from blood–retinal barrier (BRB) breakdown is a cause of significant visual loss associated with a variety of ocular disorders. BRB breakdown is a complex process that is regulated by multiple factors and involves different mechanisms. A variety of therapeutic approaches have shown modest suppression of macular edema, but to obtain greater efficacy, it is likely that multiple molecules, operating through distinct mechanisms, may need to be targeted. Studies aimed at identifying key target molecules and the optimal strategies for inhibiting them are ongoing in several laboratories. 2010 2010-07-12 /pmc/articles/PMC7150236/ http://dx.doi.org/10.1016/B978-0-12-374203-2.00137-8 Text en Copyright © 2010 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Vinores, S.A.
Breakdown of the Blood–Retinal Barrier
title Breakdown of the Blood–Retinal Barrier
title_full Breakdown of the Blood–Retinal Barrier
title_fullStr Breakdown of the Blood–Retinal Barrier
title_full_unstemmed Breakdown of the Blood–Retinal Barrier
title_short Breakdown of the Blood–Retinal Barrier
title_sort breakdown of the blood–retinal barrier
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150236/
http://dx.doi.org/10.1016/B978-0-12-374203-2.00137-8
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