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Paroxetine combined with olanzapine in the treatment of schizophrenia

OBJECTIVE: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. METHODS: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as re...

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Autores principales: Wang, Ning, Zheng, Na, Dong, Mei, He, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150422/
https://www.ncbi.nlm.nih.gov/pubmed/32292463
http://dx.doi.org/10.12669/pjms.36.3.846
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author Wang, Ning
Zheng, Na
Dong, Mei
He, Jin
author_facet Wang, Ning
Zheng, Na
Dong, Mei
He, Jin
author_sort Wang, Ning
collection PubMed
description OBJECTIVE: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. METHODS: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as research subjects and randomly divided into observation group and control group using random number table, 42 cases in each group. The control group was treated with olanzapine orally, while the observation group was treated with olanzapine and paroxetine orally. The level of homocysteine (Hcy) in the two groups was analyzed before and after treatment. The efficacy was evaluated by the Positive and Negative Symptoms Scale (PANSS) score and Hamilton Depression Scale (HAMD) score. The adverse reactions of the two groups were compared. RESULTS: After treatment, the level of serum Hcy in the observation group was significantly lower than that in the control group (P<0.05), and it was close to the normal level. There was no significant difference in PANSS score between the two groups before treatment (P>0.05). After treatment, the negative factor score and PANSS score in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The HAMD score of the two groups had no significant difference before treatment (P>0.05). After treatment, the HAMD score of the observation group was significantly lower than that of the control group (P<0.05). The difference of incidence of adverse reactions between the two groups had no statistical significance (P>0.05). CONCLUSION: Paroxetine combined with olanzapine has a definite clinical effect in the treatment of senile schizophrenia with depression. It can effectively reduce the level of serum Hcy, relieve the symptoms of schizophrenia, and alleviate the depressive symptoms of patients, with high safety. It is worth promoting.
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spelling pubmed-71504222020-04-14 Paroxetine combined with olanzapine in the treatment of schizophrenia Wang, Ning Zheng, Na Dong, Mei He, Jin Pak J Med Sci Original Article OBJECTIVE: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. METHODS: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as research subjects and randomly divided into observation group and control group using random number table, 42 cases in each group. The control group was treated with olanzapine orally, while the observation group was treated with olanzapine and paroxetine orally. The level of homocysteine (Hcy) in the two groups was analyzed before and after treatment. The efficacy was evaluated by the Positive and Negative Symptoms Scale (PANSS) score and Hamilton Depression Scale (HAMD) score. The adverse reactions of the two groups were compared. RESULTS: After treatment, the level of serum Hcy in the observation group was significantly lower than that in the control group (P<0.05), and it was close to the normal level. There was no significant difference in PANSS score between the two groups before treatment (P>0.05). After treatment, the negative factor score and PANSS score in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The HAMD score of the two groups had no significant difference before treatment (P>0.05). After treatment, the HAMD score of the observation group was significantly lower than that of the control group (P<0.05). The difference of incidence of adverse reactions between the two groups had no statistical significance (P>0.05). CONCLUSION: Paroxetine combined with olanzapine has a definite clinical effect in the treatment of senile schizophrenia with depression. It can effectively reduce the level of serum Hcy, relieve the symptoms of schizophrenia, and alleviate the depressive symptoms of patients, with high safety. It is worth promoting. Professional Medical Publications 2020 /pmc/articles/PMC7150422/ /pubmed/32292463 http://dx.doi.org/10.12669/pjms.36.3.846 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wang, Ning
Zheng, Na
Dong, Mei
He, Jin
Paroxetine combined with olanzapine in the treatment of schizophrenia
title Paroxetine combined with olanzapine in the treatment of schizophrenia
title_full Paroxetine combined with olanzapine in the treatment of schizophrenia
title_fullStr Paroxetine combined with olanzapine in the treatment of schizophrenia
title_full_unstemmed Paroxetine combined with olanzapine in the treatment of schizophrenia
title_short Paroxetine combined with olanzapine in the treatment of schizophrenia
title_sort paroxetine combined with olanzapine in the treatment of schizophrenia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150422/
https://www.ncbi.nlm.nih.gov/pubmed/32292463
http://dx.doi.org/10.12669/pjms.36.3.846
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