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Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes

Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns and thus limits clinical application of these vecto...

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Detalles Bibliográficos
Autores principales:	Kuroda, Seiji, Miyagawa, Yoshitaka, Sato, Yuriko, Yamamoto, Motoko, Adachi, Kumi, Kinoh, Hiromi, Goins, William F., Cohen, Justus B., Glorioso, Joseph C., Taniai, Nobuhiko, Yoshida, Hiroshi, Okada, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150431/ https://www.ncbi.nlm.nih.gov/pubmed/32300608 http://dx.doi.org/10.1016/j.omtm.2020.03.014

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