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The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p

Hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer mortality. Several lines of evidence have demonstrated the aberrant expression of long noncoding RNAs (lncRNAs) in carcinogenesis and their universal regulatory properties. A thorough understanding o...

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Autores principales: Lan, Xi, Wu, Nan, Wu, Litao, Qu, Kai, Osoro, Ezra Kombo, Guan, Dongxian, Du, Xiaojuan, Wang, Bo, Chen, Sifan, Miao, Ji, Ren, Juan, Liu, Li, Li, Haiyun, Ning, Qilan, Li, Dongmin, Lu, Shemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150434/
https://www.ncbi.nlm.nih.gov/pubmed/32278306
http://dx.doi.org/10.1016/j.omtn.2020.03.008
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author Lan, Xi
Wu, Nan
Wu, Litao
Qu, Kai
Osoro, Ezra Kombo
Guan, Dongxian
Du, Xiaojuan
Wang, Bo
Chen, Sifan
Miao, Ji
Ren, Juan
Liu, Li
Li, Haiyun
Ning, Qilan
Li, Dongmin
Lu, Shemin
author_facet Lan, Xi
Wu, Nan
Wu, Litao
Qu, Kai
Osoro, Ezra Kombo
Guan, Dongxian
Du, Xiaojuan
Wang, Bo
Chen, Sifan
Miao, Ji
Ren, Juan
Liu, Li
Li, Haiyun
Ning, Qilan
Li, Dongmin
Lu, Shemin
author_sort Lan, Xi
collection PubMed
description Hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer mortality. Several lines of evidence have demonstrated the aberrant expression of long noncoding RNAs (lncRNAs) in carcinogenesis and their universal regulatory properties. A thorough understanding of lncRNA regulatory roles in HCC pathology would contribute to HCC prevention and treatment. In this study, we identified a novel human lncRNA, LNC-HC, with significantly reduced levels in hepatic tumors from patients with HCC. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-dimethyltetrazolium bromide) assays as well as colony formation and wound healing experiments showed that LNC-HC significantly inhibited the proliferation of the HCC cell line Huh7. Xenograft transplantation of LNC-HC-overexpressing Huh7 cells in nude mice resulted in the production of smaller tumors. Mechanistically, LNC-HC inhibited the proliferation of HCC cells by directly interacting with hsa-miR-183-5p. LNC-HC rescued the expression of five tumor suppressors, including AKAP12, DYRK2, FOXN3, FOXO1, and LATS2, that were verified as target genes of hsa-miR-183-5p. Overall, human LNC-HC was identified as a novel tumor suppressor that could inhibit HCC cell proliferation in vitro and suppress tumor growth in vivo by competitively binding hsa-miR-183-5p as a competing endogenous RNA (ceRNA). These findings suggest that LNC-HC could be a biomarker of HCC and provide a novel therapeutic target for HCC treatment.
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spelling pubmed-71504342020-04-16 The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p Lan, Xi Wu, Nan Wu, Litao Qu, Kai Osoro, Ezra Kombo Guan, Dongxian Du, Xiaojuan Wang, Bo Chen, Sifan Miao, Ji Ren, Juan Liu, Li Li, Haiyun Ning, Qilan Li, Dongmin Lu, Shemin Mol Ther Nucleic Acids Article Hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer mortality. Several lines of evidence have demonstrated the aberrant expression of long noncoding RNAs (lncRNAs) in carcinogenesis and their universal regulatory properties. A thorough understanding of lncRNA regulatory roles in HCC pathology would contribute to HCC prevention and treatment. In this study, we identified a novel human lncRNA, LNC-HC, with significantly reduced levels in hepatic tumors from patients with HCC. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-dimethyltetrazolium bromide) assays as well as colony formation and wound healing experiments showed that LNC-HC significantly inhibited the proliferation of the HCC cell line Huh7. Xenograft transplantation of LNC-HC-overexpressing Huh7 cells in nude mice resulted in the production of smaller tumors. Mechanistically, LNC-HC inhibited the proliferation of HCC cells by directly interacting with hsa-miR-183-5p. LNC-HC rescued the expression of five tumor suppressors, including AKAP12, DYRK2, FOXN3, FOXO1, and LATS2, that were verified as target genes of hsa-miR-183-5p. Overall, human LNC-HC was identified as a novel tumor suppressor that could inhibit HCC cell proliferation in vitro and suppress tumor growth in vivo by competitively binding hsa-miR-183-5p as a competing endogenous RNA (ceRNA). These findings suggest that LNC-HC could be a biomarker of HCC and provide a novel therapeutic target for HCC treatment. American Society of Gene & Cell Therapy 2020-03-20 /pmc/articles/PMC7150434/ /pubmed/32278306 http://dx.doi.org/10.1016/j.omtn.2020.03.008 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lan, Xi
Wu, Nan
Wu, Litao
Qu, Kai
Osoro, Ezra Kombo
Guan, Dongxian
Du, Xiaojuan
Wang, Bo
Chen, Sifan
Miao, Ji
Ren, Juan
Liu, Li
Li, Haiyun
Ning, Qilan
Li, Dongmin
Lu, Shemin
The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title_full The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title_fullStr The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title_full_unstemmed The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title_short The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p
title_sort human novel gene lnc-hc inhibits hepatocellular carcinoma cell proliferation by sequestering hsa-mir-183-5p
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150434/
https://www.ncbi.nlm.nih.gov/pubmed/32278306
http://dx.doi.org/10.1016/j.omtn.2020.03.008
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