Cargando…
Gene Therapy in Cancer Treatment: Why Go Nano?
The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150812/ https://www.ncbi.nlm.nih.gov/pubmed/32151052 http://dx.doi.org/10.3390/pharmaceutics12030233 |
_version_ | 1783521104034267136 |
---|---|
author | Roma-Rodrigues, Catarina Rivas-García, Lorenzo Baptista, Pedro V. Fernandes, Alexandra R. |
author_facet | Roma-Rodrigues, Catarina Rivas-García, Lorenzo Baptista, Pedro V. Fernandes, Alexandra R. |
author_sort | Roma-Rodrigues, Catarina |
collection | PubMed |
description | The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications. |
format | Online Article Text |
id | pubmed-7150812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71508122020-04-20 Gene Therapy in Cancer Treatment: Why Go Nano? Roma-Rodrigues, Catarina Rivas-García, Lorenzo Baptista, Pedro V. Fernandes, Alexandra R. Pharmaceutics Review The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications. MDPI 2020-03-05 /pmc/articles/PMC7150812/ /pubmed/32151052 http://dx.doi.org/10.3390/pharmaceutics12030233 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Roma-Rodrigues, Catarina Rivas-García, Lorenzo Baptista, Pedro V. Fernandes, Alexandra R. Gene Therapy in Cancer Treatment: Why Go Nano? |
title | Gene Therapy in Cancer Treatment: Why Go Nano? |
title_full | Gene Therapy in Cancer Treatment: Why Go Nano? |
title_fullStr | Gene Therapy in Cancer Treatment: Why Go Nano? |
title_full_unstemmed | Gene Therapy in Cancer Treatment: Why Go Nano? |
title_short | Gene Therapy in Cancer Treatment: Why Go Nano? |
title_sort | gene therapy in cancer treatment: why go nano? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150812/ https://www.ncbi.nlm.nih.gov/pubmed/32151052 http://dx.doi.org/10.3390/pharmaceutics12030233 |
work_keys_str_mv | AT romarodriguescatarina genetherapyincancertreatmentwhygonano AT rivasgarcialorenzo genetherapyincancertreatmentwhygonano AT baptistapedrov genetherapyincancertreatmentwhygonano AT fernandesalexandrar genetherapyincancertreatmentwhygonano |