Vector-Borne Transmission of the Zika Virus Asian Genotype in Europe

Three autochthonous cases of Zika virus occurred in southern France in August 2019. Diagnosis relied on serology and transcription-mediated amplification. Attempts for virus isolation and ZIKV genome RT-PCR detection remained negative. Since the index case was not identified, we addressed the issue...

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Detalles Bibliográficos
Autores principales: Durand, Guillaume A., Piorkowski, Géraldine, Thirion, Laurence, Ninove, Laetitia, Giron, Sandra, Zandotti, Christine, Denis, Jessica, Badaut, Cyril, Failloux, Anna-Bella, Grard, Gilda, Leparc-Goffart, Isabelle, de Lamballerie, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150815/
https://www.ncbi.nlm.nih.gov/pubmed/32182748
http://dx.doi.org/10.3390/v12030296
Descripción
Sumario:Three autochthonous cases of Zika virus occurred in southern France in August 2019. Diagnosis relied on serology and transcription-mediated amplification. Attempts for virus isolation and ZIKV genome RT-PCR detection remained negative. Since the index case was not identified, we addressed the issue of genotyping and geographical origin by performing hemi-nested PCR and sequencing in the Pr gene. Analysis of 16 genotype-specific Single Nucleotides Polymorphisms identified the Asian genotype and suggested a Southeast Asia origin.

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