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Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig

African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, Europe...

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Autores principales: Pereira De Oliveira, Rémi, Hutet, Evelyne, Duhayon, Maxime, Guionnet, Jean-Marie, Paboeuf, Frédéric, Vial, Laurence, Le Potier, Marie-Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150827/
https://www.ncbi.nlm.nih.gov/pubmed/32168820
http://dx.doi.org/10.3390/v12030300
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author Pereira De Oliveira, Rémi
Hutet, Evelyne
Duhayon, Maxime
Guionnet, Jean-Marie
Paboeuf, Frédéric
Vial, Laurence
Le Potier, Marie-Frédérique
author_facet Pereira De Oliveira, Rémi
Hutet, Evelyne
Duhayon, Maxime
Guionnet, Jean-Marie
Paboeuf, Frédéric
Vial, Laurence
Le Potier, Marie-Frédérique
author_sort Pereira De Oliveira, Rémi
collection PubMed
description African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Ornithodoros erraticus and Ornithodoros verrucosus) were not able to transmit African swine fever virus by biting pigs although these ticks maintained the infectious virus during several months; therefore, the possibility for pigs to become infected through the ingestion of infected ticks was questioned but not already explored. To determine if such oral ingestion is an alternative pathway of transmission, O. erraticus ticks were infected by blood-feeding on a viremic pig infected with the European African swine fever virus strain Georgia2007/1, then frozen at zero and two months post-engorgement, then after, were embedded in the food to pigs. Pig infection was successful, with superior efficiency with ticks frozen just after the infectious blood meal. These results confirmed the potential role of O. erraticus ticks as an ASFV reservoir and demonstrated the efficiency of non-conventional pathways of transmission.
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spelling pubmed-71508272020-04-20 Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig Pereira De Oliveira, Rémi Hutet, Evelyne Duhayon, Maxime Guionnet, Jean-Marie Paboeuf, Frédéric Vial, Laurence Le Potier, Marie-Frédérique Viruses Communication African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Ornithodoros erraticus and Ornithodoros verrucosus) were not able to transmit African swine fever virus by biting pigs although these ticks maintained the infectious virus during several months; therefore, the possibility for pigs to become infected through the ingestion of infected ticks was questioned but not already explored. To determine if such oral ingestion is an alternative pathway of transmission, O. erraticus ticks were infected by blood-feeding on a viremic pig infected with the European African swine fever virus strain Georgia2007/1, then frozen at zero and two months post-engorgement, then after, were embedded in the food to pigs. Pig infection was successful, with superior efficiency with ticks frozen just after the infectious blood meal. These results confirmed the potential role of O. erraticus ticks as an ASFV reservoir and demonstrated the efficiency of non-conventional pathways of transmission. MDPI 2020-03-11 /pmc/articles/PMC7150827/ /pubmed/32168820 http://dx.doi.org/10.3390/v12030300 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pereira De Oliveira, Rémi
Hutet, Evelyne
Duhayon, Maxime
Guionnet, Jean-Marie
Paboeuf, Frédéric
Vial, Laurence
Le Potier, Marie-Frédérique
Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title_full Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title_fullStr Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title_full_unstemmed Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title_short Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig
title_sort successful infection of domestic pigs by ingestion of the european soft tick o. erraticus that fed on african swine fever virus infected pig
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150827/
https://www.ncbi.nlm.nih.gov/pubmed/32168820
http://dx.doi.org/10.3390/v12030300
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