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Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate

An important task of pharmacology is to find effective agents to improve retinal microcirculation and resistance to ischemia. The purpose of the study is to pharmacologically evaluate the retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate in a rat model of retinal ischemia–repe...

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Autores principales: Peresypkina, Anna, Pazhinsky, Anton, Danilenko, Lyudmila, Lugovskoy, Sergey, Pokrovskii, Mikhail, Beskhmelnitsyna, Evgeniya, Solovev, Nikolai, Pobeda, Anna, Korokin, Mikhail, Levkova, Elena, Gubareva, Victoria, Korokina, Liliya, Martynova, Olga, Soldatov, Vladislav, Pokrovskii, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150877/
https://www.ncbi.nlm.nih.gov/pubmed/32121045
http://dx.doi.org/10.3390/biology9030045
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author Peresypkina, Anna
Pazhinsky, Anton
Danilenko, Lyudmila
Lugovskoy, Sergey
Pokrovskii, Mikhail
Beskhmelnitsyna, Evgeniya
Solovev, Nikolai
Pobeda, Anna
Korokin, Mikhail
Levkova, Elena
Gubareva, Victoria
Korokina, Liliya
Martynova, Olga
Soldatov, Vladislav
Pokrovskii, Vladimir
author_facet Peresypkina, Anna
Pazhinsky, Anton
Danilenko, Lyudmila
Lugovskoy, Sergey
Pokrovskii, Mikhail
Beskhmelnitsyna, Evgeniya
Solovev, Nikolai
Pobeda, Anna
Korokin, Mikhail
Levkova, Elena
Gubareva, Victoria
Korokina, Liliya
Martynova, Olga
Soldatov, Vladislav
Pokrovskii, Vladimir
author_sort Peresypkina, Anna
collection PubMed
description An important task of pharmacology is to find effective agents to improve retinal microcirculation and resistance to ischemia. The purpose of the study is to pharmacologically evaluate the retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate in a rat model of retinal ischemia–reperfusion. A retinal ischemia–reperfusion model was used, in which an increase in intraocular pressure (IOP) to 110 mmHg was carried out within 30 min. The retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate at a dose of 3.8 mg/kg, in comparison with nicotinic acid at a dose of 2 mg/kg and emoxipine at a dose of 2 mg/kg, was estimated by the changes in the eye fundus during ophthalmoscopy, the retinal microcirculation level with laser Doppler flowmetry (LDF), and electroretinography (ERG) after 72 h of reperfusion. The use of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate prevented the development of ischemic injuries in the fundus and led to an increase in the retinal microcirculation level to 747 (median) (lower and upper quartiles: 693;760) perfusion units (p = 0.0002) in comparison with the group that underwent no treatment. In the group with the studied substance, the b-wave amplitude increased significantly (p = 0.0022), and the b/a coefficient increased reliably (p = 0.0002) in comparison with the group with no treatment. Thus, 2-ethyl-3-hydroxy-6-methylpyridine nicotinate has established itself as a potential retinoprotector.
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spelling pubmed-71508772020-04-20 Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate Peresypkina, Anna Pazhinsky, Anton Danilenko, Lyudmila Lugovskoy, Sergey Pokrovskii, Mikhail Beskhmelnitsyna, Evgeniya Solovev, Nikolai Pobeda, Anna Korokin, Mikhail Levkova, Elena Gubareva, Victoria Korokina, Liliya Martynova, Olga Soldatov, Vladislav Pokrovskii, Vladimir Biology (Basel) Article An important task of pharmacology is to find effective agents to improve retinal microcirculation and resistance to ischemia. The purpose of the study is to pharmacologically evaluate the retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate in a rat model of retinal ischemia–reperfusion. A retinal ischemia–reperfusion model was used, in which an increase in intraocular pressure (IOP) to 110 mmHg was carried out within 30 min. The retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate at a dose of 3.8 mg/kg, in comparison with nicotinic acid at a dose of 2 mg/kg and emoxipine at a dose of 2 mg/kg, was estimated by the changes in the eye fundus during ophthalmoscopy, the retinal microcirculation level with laser Doppler flowmetry (LDF), and electroretinography (ERG) after 72 h of reperfusion. The use of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate prevented the development of ischemic injuries in the fundus and led to an increase in the retinal microcirculation level to 747 (median) (lower and upper quartiles: 693;760) perfusion units (p = 0.0002) in comparison with the group that underwent no treatment. In the group with the studied substance, the b-wave amplitude increased significantly (p = 0.0022), and the b/a coefficient increased reliably (p = 0.0002) in comparison with the group with no treatment. Thus, 2-ethyl-3-hydroxy-6-methylpyridine nicotinate has established itself as a potential retinoprotector. MDPI 2020-02-28 /pmc/articles/PMC7150877/ /pubmed/32121045 http://dx.doi.org/10.3390/biology9030045 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peresypkina, Anna
Pazhinsky, Anton
Danilenko, Lyudmila
Lugovskoy, Sergey
Pokrovskii, Mikhail
Beskhmelnitsyna, Evgeniya
Solovev, Nikolai
Pobeda, Anna
Korokin, Mikhail
Levkova, Elena
Gubareva, Victoria
Korokina, Liliya
Martynova, Olga
Soldatov, Vladislav
Pokrovskii, Vladimir
Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title_full Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title_fullStr Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title_full_unstemmed Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title_short Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate
title_sort retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150877/
https://www.ncbi.nlm.nih.gov/pubmed/32121045
http://dx.doi.org/10.3390/biology9030045
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