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Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. This loop is important for anchoring elongation factor (EF-G for prokaryote or eEF2 for eukaryote) in mRNA translocation. Translation is inhibit...

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Detalles Bibliográficos
Autores principales:	Lu, Jia-Qi, Zhu, Zhen-Ning, Zheng, Yong-Tang, Shaw, Pang-Chui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150887/ https://www.ncbi.nlm.nih.gov/pubmed/32182799 http://dx.doi.org/10.3390/toxins12030167

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