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A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species

Many pathogenic Candida species possess the ability to undergo a reversible morphological transition from yeast to filamentous cells. In Candida albicans, the most frequently isolated human fungal pathogen, multiple lines of evidence strongly suggest that this transition is associated with virulence...

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Autores principales: Kadosh, David, Mundodi, Vasanthakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151024/
https://www.ncbi.nlm.nih.gov/pubmed/31940968
http://dx.doi.org/10.3390/jof6010013
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author Kadosh, David
Mundodi, Vasanthakrishna
author_facet Kadosh, David
Mundodi, Vasanthakrishna
author_sort Kadosh, David
collection PubMed
description Many pathogenic Candida species possess the ability to undergo a reversible morphological transition from yeast to filamentous cells. In Candida albicans, the most frequently isolated human fungal pathogen, multiple lines of evidence strongly suggest that this transition is associated with virulence and pathogenicity. While it has generally been assumed that non-albicans Candida species (NACS) are less pathogenic than C. albicans, in part, because they do not filament as well, definitive evidence is lacking. Interestingly, however, a recent study suggests that filamentation of NACS is associated with reduced, rather than increased, pathogenicity. These findings, in turn, challenge conventional views and suggest that there are fundamental evolutionary differences in the morphology–pathogenicity relationship in C. albicans vs. NACS. The findings also raise many new and intriguing questions and open new avenues for future research, which are discussed.
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spelling pubmed-71510242020-04-20 A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species Kadosh, David Mundodi, Vasanthakrishna J Fungi (Basel) Review Many pathogenic Candida species possess the ability to undergo a reversible morphological transition from yeast to filamentous cells. In Candida albicans, the most frequently isolated human fungal pathogen, multiple lines of evidence strongly suggest that this transition is associated with virulence and pathogenicity. While it has generally been assumed that non-albicans Candida species (NACS) are less pathogenic than C. albicans, in part, because they do not filament as well, definitive evidence is lacking. Interestingly, however, a recent study suggests that filamentation of NACS is associated with reduced, rather than increased, pathogenicity. These findings, in turn, challenge conventional views and suggest that there are fundamental evolutionary differences in the morphology–pathogenicity relationship in C. albicans vs. NACS. The findings also raise many new and intriguing questions and open new avenues for future research, which are discussed. MDPI 2020-01-13 /pmc/articles/PMC7151024/ /pubmed/31940968 http://dx.doi.org/10.3390/jof6010013 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kadosh, David
Mundodi, Vasanthakrishna
A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title_full A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title_fullStr A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title_full_unstemmed A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title_short A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
title_sort re-evaluation of the relationship between morphology and pathogenicity in candida species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151024/
https://www.ncbi.nlm.nih.gov/pubmed/31940968
http://dx.doi.org/10.3390/jof6010013
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