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Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches
The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151031/ https://www.ncbi.nlm.nih.gov/pubmed/32245190 http://dx.doi.org/10.3390/pharmaceutics12030282 |
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author | Zhang, Julia Froelich, Anna Michniak-Kohn, Bozena |
author_facet | Zhang, Julia Froelich, Anna Michniak-Kohn, Bozena |
author_sort | Zhang, Julia |
collection | PubMed |
description | The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. For microemulsions, particle size, electrical conductivity and viscosity studies were performed to assess the structure of the investigated systems. An ex vivo skin permeation study has been conducted to compare these formulations. The dermal and transdermal delivery of meloxicam using these formulations can be a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced side effects. |
format | Online Article Text |
id | pubmed-7151031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71510312020-04-20 Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches Zhang, Julia Froelich, Anna Michniak-Kohn, Bozena Pharmaceutics Article The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. For microemulsions, particle size, electrical conductivity and viscosity studies were performed to assess the structure of the investigated systems. An ex vivo skin permeation study has been conducted to compare these formulations. The dermal and transdermal delivery of meloxicam using these formulations can be a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced side effects. MDPI 2020-03-21 /pmc/articles/PMC7151031/ /pubmed/32245190 http://dx.doi.org/10.3390/pharmaceutics12030282 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Julia Froelich, Anna Michniak-Kohn, Bozena Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title | Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title_full | Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title_fullStr | Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title_full_unstemmed | Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title_short | Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches |
title_sort | topical delivery of meloxicam using liposome and microemulsion formulation approaches |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151031/ https://www.ncbi.nlm.nih.gov/pubmed/32245190 http://dx.doi.org/10.3390/pharmaceutics12030282 |
work_keys_str_mv | AT zhangjulia topicaldeliveryofmeloxicamusingliposomeandmicroemulsionformulationapproaches AT froelichanna topicaldeliveryofmeloxicamusingliposomeandmicroemulsionformulationapproaches AT michniakkohnbozena topicaldeliveryofmeloxicamusingliposomeandmicroemulsionformulationapproaches |