The Role of Secretory Pathways in Candida albicans Pathogenesis

Candida albicans is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm form...

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Autores principales: Rollenhagen, Christiane, Mamtani, Sahil, Ma, Dakota, Dixit, Reva, Eszterhas, Susan, Lee, Samuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151058/
https://www.ncbi.nlm.nih.gov/pubmed/32102426
http://dx.doi.org/10.3390/jof6010026
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author Rollenhagen, Christiane
Mamtani, Sahil
Ma, Dakota
Dixit, Reva
Eszterhas, Susan
Lee, Samuel A.
author_facet Rollenhagen, Christiane
Mamtani, Sahil
Ma, Dakota
Dixit, Reva
Eszterhas, Susan
Lee, Samuel A.
author_sort Rollenhagen, Christiane
collection PubMed
description Candida albicans is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm formation. These processes are supported by secretion, as defined in the broad context of membrane trafficking. In this review, we examine the role of secretory pathways in Candida virulence, with a focus on the model opportunistic fungal pathogen, Candida albicans.
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spelling pubmed-71510582020-04-20 The Role of Secretory Pathways in Candida albicans Pathogenesis Rollenhagen, Christiane Mamtani, Sahil Ma, Dakota Dixit, Reva Eszterhas, Susan Lee, Samuel A. J Fungi (Basel) Review Candida albicans is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm formation. These processes are supported by secretion, as defined in the broad context of membrane trafficking. In this review, we examine the role of secretory pathways in Candida virulence, with a focus on the model opportunistic fungal pathogen, Candida albicans. MDPI 2020-02-24 /pmc/articles/PMC7151058/ /pubmed/32102426 http://dx.doi.org/10.3390/jof6010026 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rollenhagen, Christiane
Mamtani, Sahil
Ma, Dakota
Dixit, Reva
Eszterhas, Susan
Lee, Samuel A.
The Role of Secretory Pathways in Candida albicans Pathogenesis
title The Role of Secretory Pathways in Candida albicans Pathogenesis
title_full The Role of Secretory Pathways in Candida albicans Pathogenesis
title_fullStr The Role of Secretory Pathways in Candida albicans Pathogenesis
title_full_unstemmed The Role of Secretory Pathways in Candida albicans Pathogenesis
title_short The Role of Secretory Pathways in Candida albicans Pathogenesis
title_sort role of secretory pathways in candida albicans pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151058/
https://www.ncbi.nlm.nih.gov/pubmed/32102426
http://dx.doi.org/10.3390/jof6010026
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