Cargando…

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

Alzheimer’s disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment. Nevertheless, clinical results are discouraging. In vivo efficacy of the RL-208, a new NMDA r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Companys-Alemany, Júlia, Turcu, Andreea L., Bellver-Sanchis, Aina, Loza, Maria I, Brea, José M., Canudas, Anna M, Leiva, Rosana, Vázquez, Santiago, Pallàs, Mercè, Griñán-Ferré, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151078/ https://www.ncbi.nlm.nih.gov/pubmed/32235699 http://dx.doi.org/10.3390/pharmaceutics12030284

Ejemplares similares

Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease
por: Bellver-Sanchis, Aina, et al.
Publicado: (2021)

Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Cognitive Decline and BPSD Are Concomitant with Autophagic and Synaptic Deficits Associated with G9a Alterations in Aged SAMP8 Mice
por: Vasilopoulou, Foteini, et al.
Publicado: (2022)

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
por: Izquierdo, Vanesa, et al.
Publicado: (2019)

Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents
por: Bellver‐Sanchis, Aina, et al.
Publicado: (2022)

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models
por: Jarne-Ferrer, Júlia, et al.
Publicado: (2022)

Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2021)

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model
por: Griñán-Ferré, Christian, et al.
Publicado: (2019)

RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
por: Pawar, Shrikant, et al.
Publicado: (2021)

Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline
por: Cosín-Tomás, Marta, et al.
Publicado: (2018)

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2020)

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection
por: Griñan-Ferré, Christian, et al.
Publicado: (2016)

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy
por: Pallàs, Mercè, et al.
Publicado: (2020)

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I(2)-Imidazoline Receptor Ligand MCR5
por: Vasilopoulou, Foteini, et al.
Publicado: (2020)

Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model
por: Vasilopoulou, Foteini, et al.
Publicado: (2021)

Correction: Izquierdo et al. Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Int. J. Mol. Sci. 2021, 22, 1453
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2020)

Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I(2) Receptor Ligand B06
por: Bagán, Andrea, et al.
Publicado: (2022)

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
por: Roig‐Soriano, J., et al.
Publicado: (2022)

The Role of the miR-17-92 Cluster in Autophagy and Atherosclerosis Supports Its Link to Lysosomal Storage Diseases
por: Ortuño-Sahagún, Daniel, et al.
Publicado: (2022)

Neuroprotective Effects of Resveratrol by Modifying Cholesterol Metabolism and Aβ Processing in SAMP8 Mice
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2022)

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins
por: Avila, Jesús, et al.
Publicado: (2017)

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
por: Griñán-Ferré, Christian, et al.
Publicado: (2016)

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
por: Codony, Sandra, et al.
Publicado: (2021)

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

Reply to Nifli, A.-P. Comment on “Rosell-Cardona et al. Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice. Nutrients 2021, 13, 2369”
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis
por: Rosell-Cardona, Cristina, et al.
Publicado: (2022)

NMDA Receptor Antagonists for Treatment of Depression
por: Ates-Alagoz, Zeynep, et al.
Publicado: (2013)

Inhibition of NMDA receptors through a membrane-to-channel path
por: Wilcox, Madeleine R., et al.
Publicado: (2022)

Allosteric antagonist action at triheteromeric NMDA receptors
por: Gibb, Alasdair J.
Publicado: (2022)

Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague–Dawley rats
por: Roglans, Nuria, et al.
Publicado: (2021)

Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer′s Disease Neurodegeneration
por: Bartra, Clara, et al.
Publicado: (2022)

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease
por: Codony, Sandra, et al.
Publicado: (2022)

Global DNA Methylation and Hydroxymethylation Levels in PBMCs Are Altered in RRMS Patients Treated with IFN-β and GA—A Preliminary Study
por: Reyes-Mata, María Paulina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jd577h3s6a6q274pu1r1ljvsr1