Cargando…
Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value o...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151108/ https://www.ncbi.nlm.nih.gov/pubmed/32178485 http://dx.doi.org/10.3390/diagnostics10030154 |
_version_ | 1783521174122135552 |
---|---|
author | Shimizu, Takuto Miyake, Makito Hori, Shunta Iida, Kota Ichikawa, Kazuki Sakamoto, Keiichi Miyamoto, Tatsuki Nakai, Yasushi Inoue, Takeshi Anai, Satoshi Tanaka, Nobumichi Fujimoto, Kiyohide |
author_facet | Shimizu, Takuto Miyake, Makito Hori, Shunta Iida, Kota Ichikawa, Kazuki Sakamoto, Keiichi Miyamoto, Tatsuki Nakai, Yasushi Inoue, Takeshi Anai, Satoshi Tanaka, Nobumichi Fujimoto, Kiyohide |
author_sort | Shimizu, Takuto |
collection | PubMed |
description | The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value or recurrence rate. We investigated the recurrence rate based on tumor size, pathological invasion sites including urinary collecting system invasion (UCSI), and clinically detected renal vein thrombus (cd-RVT) with pT3aN0M0 RCC. We retrospectively reviewed 91 patients with pT3aN0M0 RCC who underwent surgical treatment. Patients with tumor size > 7 cm, UCSI, three invasive sites (PFI + SFI + RVI), and cd-RVT showed a significant correlation with high recurrence rates (hazard ration (HR) 2.98, p = 0.013; HR 8.86, p < 0.0001; HR 14.28, p = 0.0008; and HR 4.08, p = 0.0074, respectively). In the multivariate analysis, tumor size of >7 cm, the presence of UCSI, and cd-RVT were the independent predictors of recurrence (HR 3.39, p = 0.043, HR 7.31, p = 0.01, HR 5.06, p = 0.018, respectively). In pT3a RCC, tumor size (7 cm cut-off), UCSI, and cd-RVT may help to provide an early diagnosis of recurrence. |
format | Online Article Text |
id | pubmed-7151108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71511082020-04-20 Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma Shimizu, Takuto Miyake, Makito Hori, Shunta Iida, Kota Ichikawa, Kazuki Sakamoto, Keiichi Miyamoto, Tatsuki Nakai, Yasushi Inoue, Takeshi Anai, Satoshi Tanaka, Nobumichi Fujimoto, Kiyohide Diagnostics (Basel) Article The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value or recurrence rate. We investigated the recurrence rate based on tumor size, pathological invasion sites including urinary collecting system invasion (UCSI), and clinically detected renal vein thrombus (cd-RVT) with pT3aN0M0 RCC. We retrospectively reviewed 91 patients with pT3aN0M0 RCC who underwent surgical treatment. Patients with tumor size > 7 cm, UCSI, three invasive sites (PFI + SFI + RVI), and cd-RVT showed a significant correlation with high recurrence rates (hazard ration (HR) 2.98, p = 0.013; HR 8.86, p < 0.0001; HR 14.28, p = 0.0008; and HR 4.08, p = 0.0074, respectively). In the multivariate analysis, tumor size of >7 cm, the presence of UCSI, and cd-RVT were the independent predictors of recurrence (HR 3.39, p = 0.043, HR 7.31, p = 0.01, HR 5.06, p = 0.018, respectively). In pT3a RCC, tumor size (7 cm cut-off), UCSI, and cd-RVT may help to provide an early diagnosis of recurrence. MDPI 2020-03-12 /pmc/articles/PMC7151108/ /pubmed/32178485 http://dx.doi.org/10.3390/diagnostics10030154 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shimizu, Takuto Miyake, Makito Hori, Shunta Iida, Kota Ichikawa, Kazuki Sakamoto, Keiichi Miyamoto, Tatsuki Nakai, Yasushi Inoue, Takeshi Anai, Satoshi Tanaka, Nobumichi Fujimoto, Kiyohide Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title | Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title_full | Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title_fullStr | Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title_full_unstemmed | Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title_short | Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma |
title_sort | clinical significance of tumor size, pathological invasion sites including urinary collecting system and clinically detected renal vein thrombus as predictors for recurrence in pt3a localized renal cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151108/ https://www.ncbi.nlm.nih.gov/pubmed/32178485 http://dx.doi.org/10.3390/diagnostics10030154 |
work_keys_str_mv | AT shimizutakuto clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT miyakemakito clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT horishunta clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT iidakota clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT ichikawakazuki clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT sakamotokeiichi clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT miyamototatsuki clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT nakaiyasushi clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT inouetakeshi clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT anaisatoshi clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT tanakanobumichi clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma AT fujimotokiyohide clinicalsignificanceoftumorsizepathologicalinvasionsitesincludingurinarycollectingsystemandclinicallydetectedrenalveinthrombusaspredictorsforrecurrenceinpt3alocalizedrenalcellcarcinoma |