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Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma

The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value o...

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Autores principales: Shimizu, Takuto, Miyake, Makito, Hori, Shunta, Iida, Kota, Ichikawa, Kazuki, Sakamoto, Keiichi, Miyamoto, Tatsuki, Nakai, Yasushi, Inoue, Takeshi, Anai, Satoshi, Tanaka, Nobumichi, Fujimoto, Kiyohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151108/
https://www.ncbi.nlm.nih.gov/pubmed/32178485
http://dx.doi.org/10.3390/diagnostics10030154
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author Shimizu, Takuto
Miyake, Makito
Hori, Shunta
Iida, Kota
Ichikawa, Kazuki
Sakamoto, Keiichi
Miyamoto, Tatsuki
Nakai, Yasushi
Inoue, Takeshi
Anai, Satoshi
Tanaka, Nobumichi
Fujimoto, Kiyohide
author_facet Shimizu, Takuto
Miyake, Makito
Hori, Shunta
Iida, Kota
Ichikawa, Kazuki
Sakamoto, Keiichi
Miyamoto, Tatsuki
Nakai, Yasushi
Inoue, Takeshi
Anai, Satoshi
Tanaka, Nobumichi
Fujimoto, Kiyohide
author_sort Shimizu, Takuto
collection PubMed
description The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value or recurrence rate. We investigated the recurrence rate based on tumor size, pathological invasion sites including urinary collecting system invasion (UCSI), and clinically detected renal vein thrombus (cd-RVT) with pT3aN0M0 RCC. We retrospectively reviewed 91 patients with pT3aN0M0 RCC who underwent surgical treatment. Patients with tumor size > 7 cm, UCSI, three invasive sites (PFI + SFI + RVI), and cd-RVT showed a significant correlation with high recurrence rates (hazard ration (HR) 2.98, p = 0.013; HR 8.86, p < 0.0001; HR 14.28, p = 0.0008; and HR 4.08, p = 0.0074, respectively). In the multivariate analysis, tumor size of >7 cm, the presence of UCSI, and cd-RVT were the independent predictors of recurrence (HR 3.39, p = 0.043, HR 7.31, p = 0.01, HR 5.06, p = 0.018, respectively). In pT3a RCC, tumor size (7 cm cut-off), UCSI, and cd-RVT may help to provide an early diagnosis of recurrence.
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spelling pubmed-71511082020-04-20 Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma Shimizu, Takuto Miyake, Makito Hori, Shunta Iida, Kota Ichikawa, Kazuki Sakamoto, Keiichi Miyamoto, Tatsuki Nakai, Yasushi Inoue, Takeshi Anai, Satoshi Tanaka, Nobumichi Fujimoto, Kiyohide Diagnostics (Basel) Article The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value or recurrence rate. We investigated the recurrence rate based on tumor size, pathological invasion sites including urinary collecting system invasion (UCSI), and clinically detected renal vein thrombus (cd-RVT) with pT3aN0M0 RCC. We retrospectively reviewed 91 patients with pT3aN0M0 RCC who underwent surgical treatment. Patients with tumor size > 7 cm, UCSI, three invasive sites (PFI + SFI + RVI), and cd-RVT showed a significant correlation with high recurrence rates (hazard ration (HR) 2.98, p = 0.013; HR 8.86, p < 0.0001; HR 14.28, p = 0.0008; and HR 4.08, p = 0.0074, respectively). In the multivariate analysis, tumor size of >7 cm, the presence of UCSI, and cd-RVT were the independent predictors of recurrence (HR 3.39, p = 0.043, HR 7.31, p = 0.01, HR 5.06, p = 0.018, respectively). In pT3a RCC, tumor size (7 cm cut-off), UCSI, and cd-RVT may help to provide an early diagnosis of recurrence. MDPI 2020-03-12 /pmc/articles/PMC7151108/ /pubmed/32178485 http://dx.doi.org/10.3390/diagnostics10030154 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimizu, Takuto
Miyake, Makito
Hori, Shunta
Iida, Kota
Ichikawa, Kazuki
Sakamoto, Keiichi
Miyamoto, Tatsuki
Nakai, Yasushi
Inoue, Takeshi
Anai, Satoshi
Tanaka, Nobumichi
Fujimoto, Kiyohide
Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title_full Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title_fullStr Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title_full_unstemmed Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title_short Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma
title_sort clinical significance of tumor size, pathological invasion sites including urinary collecting system and clinically detected renal vein thrombus as predictors for recurrence in pt3a localized renal cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151108/
https://www.ncbi.nlm.nih.gov/pubmed/32178485
http://dx.doi.org/10.3390/diagnostics10030154
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