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Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy

Background: Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Methods: Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine...

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Autores principales: Dal Monte, Massimo, Cammalleri, Maurizio, Pezzino, Salvatore, Corsaro, Roberta, Pescosolido, Nicola, Bagnoli, Paola, Rusciano, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151109/
https://www.ncbi.nlm.nih.gov/pubmed/32138160
http://dx.doi.org/10.3390/diagnostics10030138
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author Dal Monte, Massimo
Cammalleri, Maurizio
Pezzino, Salvatore
Corsaro, Roberta
Pescosolido, Nicola
Bagnoli, Paola
Rusciano, Dario
author_facet Dal Monte, Massimo
Cammalleri, Maurizio
Pezzino, Salvatore
Corsaro, Roberta
Pescosolido, Nicola
Bagnoli, Paola
Rusciano, Dario
author_sort Dal Monte, Massimo
collection PubMed
description Background: Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Methods: Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine. Ocular hypertension was induced by the injection of methylcellulose in the anterior chamber. Results: Melatonin formulated in nanomicelles had a longer lasting hypotonizing effect on IOP with respect to melatonin in saline. Nanomicellar formulations of melatonin and agomelatine, either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect. The duration of the lowering effect was further increased by the addition of lipoic acid. Conclusions: We demonstrated the effective hypotonizing activity of melatonin and agomelatine in combination with lipoic acid. Although results in animals cannot be directly translated to humans, the possibility of developing novel therapeutical approaches for patients suffering from hypertensive glaucoma should be considered.
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spelling pubmed-71511092020-04-20 Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy Dal Monte, Massimo Cammalleri, Maurizio Pezzino, Salvatore Corsaro, Roberta Pescosolido, Nicola Bagnoli, Paola Rusciano, Dario Diagnostics (Basel) Article Background: Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat. Methods: Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine. Ocular hypertension was induced by the injection of methylcellulose in the anterior chamber. Results: Melatonin formulated in nanomicelles had a longer lasting hypotonizing effect on IOP with respect to melatonin in saline. Nanomicellar formulations of melatonin and agomelatine, either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect. The duration of the lowering effect was further increased by the addition of lipoic acid. Conclusions: We demonstrated the effective hypotonizing activity of melatonin and agomelatine in combination with lipoic acid. Although results in animals cannot be directly translated to humans, the possibility of developing novel therapeutical approaches for patients suffering from hypertensive glaucoma should be considered. MDPI 2020-03-03 /pmc/articles/PMC7151109/ /pubmed/32138160 http://dx.doi.org/10.3390/diagnostics10030138 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dal Monte, Massimo
Cammalleri, Maurizio
Pezzino, Salvatore
Corsaro, Roberta
Pescosolido, Nicola
Bagnoli, Paola
Rusciano, Dario
Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title_full Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title_fullStr Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title_full_unstemmed Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title_short Hypotensive Effect of Nanomicellar Formulation of Melatonin and Agomelatine in a Rat Model: Significance for Glaucoma Therapy
title_sort hypotensive effect of nanomicellar formulation of melatonin and agomelatine in a rat model: significance for glaucoma therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151109/
https://www.ncbi.nlm.nih.gov/pubmed/32138160
http://dx.doi.org/10.3390/diagnostics10030138
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