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Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon

Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The...

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Autores principales: Małek, Łukasz A., Czajkowska, Anna, Mróz, Anna, Witek, Katarzyna, Nowicki, Dariusz, Postuła, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151175/
https://www.ncbi.nlm.nih.gov/pubmed/32204320
http://dx.doi.org/10.3390/diagnostics10030167
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author Małek, Łukasz A.
Czajkowska, Anna
Mróz, Anna
Witek, Katarzyna
Nowicki, Dariusz
Postuła, Marek
author_facet Małek, Łukasz A.
Czajkowska, Anna
Mróz, Anna
Witek, Katarzyna
Nowicki, Dariusz
Postuła, Marek
author_sort Małek, Łukasz A.
collection PubMed
description Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy volunteers (median age 41.5 years, interquartile range – IQR 36–53 years, 83% male) who participated in a 100 km running ultra-marathon. Information on demographic characteristics, pre- and post-race heart rate, blood pressure, body composition and glucose, lactate (L), troponin T (hs-TnT) and C reactive protein (hs-CRP) concentration were obtained. Additionally, data on L and glucose levels every 9.2 km and fluid/food intakes during the race were collected. Results: There was a significant hs-TnT increase after the race exceeding upper reference values in 66% of runners (from 5 IQR 3–7 ng/L to 14 IQR 12–26 ng/L, p < 0.0001). None of the baseline parameters predicted a post-race hs-TnT increase. The only factors, correlating with changes of hs-TnT were mean L concentration during the race (rho = 0.52, p = 0.03) and change of hs-CRP concentration (rho = 0.59, p = 0.01). Conclusions: Participation in a 100 km ultra-marathon leads to a modest, but significant hs-TnT increase in the majority of runners. Among analysed parameters only mean lactate concentration during the race and change in hs-CRP correlated with troponin change.
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spelling pubmed-71511752020-04-20 Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon Małek, Łukasz A. Czajkowska, Anna Mróz, Anna Witek, Katarzyna Nowicki, Dariusz Postuła, Marek Diagnostics (Basel) Article Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy volunteers (median age 41.5 years, interquartile range – IQR 36–53 years, 83% male) who participated in a 100 km running ultra-marathon. Information on demographic characteristics, pre- and post-race heart rate, blood pressure, body composition and glucose, lactate (L), troponin T (hs-TnT) and C reactive protein (hs-CRP) concentration were obtained. Additionally, data on L and glucose levels every 9.2 km and fluid/food intakes during the race were collected. Results: There was a significant hs-TnT increase after the race exceeding upper reference values in 66% of runners (from 5 IQR 3–7 ng/L to 14 IQR 12–26 ng/L, p < 0.0001). None of the baseline parameters predicted a post-race hs-TnT increase. The only factors, correlating with changes of hs-TnT were mean L concentration during the race (rho = 0.52, p = 0.03) and change of hs-CRP concentration (rho = 0.59, p = 0.01). Conclusions: Participation in a 100 km ultra-marathon leads to a modest, but significant hs-TnT increase in the majority of runners. Among analysed parameters only mean lactate concentration during the race and change in hs-CRP correlated with troponin change. MDPI 2020-03-19 /pmc/articles/PMC7151175/ /pubmed/32204320 http://dx.doi.org/10.3390/diagnostics10030167 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Małek, Łukasz A.
Czajkowska, Anna
Mróz, Anna
Witek, Katarzyna
Nowicki, Dariusz
Postuła, Marek
Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title_full Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title_fullStr Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title_full_unstemmed Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title_short Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
title_sort factors related to cardiac troponin t increase after participation in a 100 km ultra-marathon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151175/
https://www.ncbi.nlm.nih.gov/pubmed/32204320
http://dx.doi.org/10.3390/diagnostics10030167
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