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Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon
Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151175/ https://www.ncbi.nlm.nih.gov/pubmed/32204320 http://dx.doi.org/10.3390/diagnostics10030167 |
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author | Małek, Łukasz A. Czajkowska, Anna Mróz, Anna Witek, Katarzyna Nowicki, Dariusz Postuła, Marek |
author_facet | Małek, Łukasz A. Czajkowska, Anna Mróz, Anna Witek, Katarzyna Nowicki, Dariusz Postuła, Marek |
author_sort | Małek, Łukasz A. |
collection | PubMed |
description | Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy volunteers (median age 41.5 years, interquartile range – IQR 36–53 years, 83% male) who participated in a 100 km running ultra-marathon. Information on demographic characteristics, pre- and post-race heart rate, blood pressure, body composition and glucose, lactate (L), troponin T (hs-TnT) and C reactive protein (hs-CRP) concentration were obtained. Additionally, data on L and glucose levels every 9.2 km and fluid/food intakes during the race were collected. Results: There was a significant hs-TnT increase after the race exceeding upper reference values in 66% of runners (from 5 IQR 3–7 ng/L to 14 IQR 12–26 ng/L, p < 0.0001). None of the baseline parameters predicted a post-race hs-TnT increase. The only factors, correlating with changes of hs-TnT were mean L concentration during the race (rho = 0.52, p = 0.03) and change of hs-CRP concentration (rho = 0.59, p = 0.01). Conclusions: Participation in a 100 km ultra-marathon leads to a modest, but significant hs-TnT increase in the majority of runners. Among analysed parameters only mean lactate concentration during the race and change in hs-CRP correlated with troponin change. |
format | Online Article Text |
id | pubmed-7151175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71511752020-04-20 Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon Małek, Łukasz A. Czajkowska, Anna Mróz, Anna Witek, Katarzyna Nowicki, Dariusz Postuła, Marek Diagnostics (Basel) Article Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy volunteers (median age 41.5 years, interquartile range – IQR 36–53 years, 83% male) who participated in a 100 km running ultra-marathon. Information on demographic characteristics, pre- and post-race heart rate, blood pressure, body composition and glucose, lactate (L), troponin T (hs-TnT) and C reactive protein (hs-CRP) concentration were obtained. Additionally, data on L and glucose levels every 9.2 km and fluid/food intakes during the race were collected. Results: There was a significant hs-TnT increase after the race exceeding upper reference values in 66% of runners (from 5 IQR 3–7 ng/L to 14 IQR 12–26 ng/L, p < 0.0001). None of the baseline parameters predicted a post-race hs-TnT increase. The only factors, correlating with changes of hs-TnT were mean L concentration during the race (rho = 0.52, p = 0.03) and change of hs-CRP concentration (rho = 0.59, p = 0.01). Conclusions: Participation in a 100 km ultra-marathon leads to a modest, but significant hs-TnT increase in the majority of runners. Among analysed parameters only mean lactate concentration during the race and change in hs-CRP correlated with troponin change. MDPI 2020-03-19 /pmc/articles/PMC7151175/ /pubmed/32204320 http://dx.doi.org/10.3390/diagnostics10030167 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Małek, Łukasz A. Czajkowska, Anna Mróz, Anna Witek, Katarzyna Nowicki, Dariusz Postuła, Marek Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title | Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title_full | Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title_fullStr | Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title_full_unstemmed | Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title_short | Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon |
title_sort | factors related to cardiac troponin t increase after participation in a 100 km ultra-marathon |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151175/ https://www.ncbi.nlm.nih.gov/pubmed/32204320 http://dx.doi.org/10.3390/diagnostics10030167 |
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