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Game of Tissues: How the Epidermis Thrones C. elegans Shape
The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151205/ https://www.ncbi.nlm.nih.gov/pubmed/32182901 http://dx.doi.org/10.3390/jdb8010007 |
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author | Carvalho, Cátia A. Broday, Limor |
author_facet | Carvalho, Cátia A. Broday, Limor |
author_sort | Carvalho, Cátia A. |
collection | PubMed |
description | The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the C. elegans embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode C. elegans. Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process. |
format | Online Article Text |
id | pubmed-7151205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71512052020-04-20 Game of Tissues: How the Epidermis Thrones C. elegans Shape Carvalho, Cátia A. Broday, Limor J Dev Biol Review The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the C. elegans embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode C. elegans. Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process. MDPI 2020-03-09 /pmc/articles/PMC7151205/ /pubmed/32182901 http://dx.doi.org/10.3390/jdb8010007 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carvalho, Cátia A. Broday, Limor Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title | Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title_full | Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title_fullStr | Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title_full_unstemmed | Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title_short | Game of Tissues: How the Epidermis Thrones C. elegans Shape |
title_sort | game of tissues: how the epidermis thrones c. elegans shape |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151205/ https://www.ncbi.nlm.nih.gov/pubmed/32182901 http://dx.doi.org/10.3390/jdb8010007 |
work_keys_str_mv | AT carvalhocatiaa gameoftissueshowtheepidermisthronescelegansshape AT brodaylimor gameoftissueshowtheepidermisthronescelegansshape |