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Monoclonal Antibodies as Tools to Combat Fungal Infections

Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a...

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Detalles Bibliográficos
Autores principales: Ulrich, Sebastian, Ebel, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151206/
https://www.ncbi.nlm.nih.gov/pubmed/32033168
http://dx.doi.org/10.3390/jof6010022
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author Ulrich, Sebastian
Ebel, Frank
author_facet Ulrich, Sebastian
Ebel, Frank
author_sort Ulrich, Sebastian
collection PubMed
description Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a successful clearance of fungal infections; however this perception has been challenged by a large number of studies over the last three decades. In this review, we focus on the potential therapeutic and prophylactic use of monoclonal antibodies. Since systemic mycoses normally occur in severely immunocompromised patients, a passive immunization using monoclonal antibodies is a promising approach to directly attack the fungal pathogen and/or to activate and strengthen the residual antifungal immune response in these patients.
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spelling pubmed-71512062020-04-20 Monoclonal Antibodies as Tools to Combat Fungal Infections Ulrich, Sebastian Ebel, Frank J Fungi (Basel) Review Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a successful clearance of fungal infections; however this perception has been challenged by a large number of studies over the last three decades. In this review, we focus on the potential therapeutic and prophylactic use of monoclonal antibodies. Since systemic mycoses normally occur in severely immunocompromised patients, a passive immunization using monoclonal antibodies is a promising approach to directly attack the fungal pathogen and/or to activate and strengthen the residual antifungal immune response in these patients. MDPI 2020-02-04 /pmc/articles/PMC7151206/ /pubmed/32033168 http://dx.doi.org/10.3390/jof6010022 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ulrich, Sebastian
Ebel, Frank
Monoclonal Antibodies as Tools to Combat Fungal Infections
title Monoclonal Antibodies as Tools to Combat Fungal Infections
title_full Monoclonal Antibodies as Tools to Combat Fungal Infections
title_fullStr Monoclonal Antibodies as Tools to Combat Fungal Infections
title_full_unstemmed Monoclonal Antibodies as Tools to Combat Fungal Infections
title_short Monoclonal Antibodies as Tools to Combat Fungal Infections
title_sort monoclonal antibodies as tools to combat fungal infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151206/
https://www.ncbi.nlm.nih.gov/pubmed/32033168
http://dx.doi.org/10.3390/jof6010022
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