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Monoclonal Antibodies as Tools to Combat Fungal Infections
Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151206/ https://www.ncbi.nlm.nih.gov/pubmed/32033168 http://dx.doi.org/10.3390/jof6010022 |
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author | Ulrich, Sebastian Ebel, Frank |
author_facet | Ulrich, Sebastian Ebel, Frank |
author_sort | Ulrich, Sebastian |
collection | PubMed |
description | Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a successful clearance of fungal infections; however this perception has been challenged by a large number of studies over the last three decades. In this review, we focus on the potential therapeutic and prophylactic use of monoclonal antibodies. Since systemic mycoses normally occur in severely immunocompromised patients, a passive immunization using monoclonal antibodies is a promising approach to directly attack the fungal pathogen and/or to activate and strengthen the residual antifungal immune response in these patients. |
format | Online Article Text |
id | pubmed-7151206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71512062020-04-20 Monoclonal Antibodies as Tools to Combat Fungal Infections Ulrich, Sebastian Ebel, Frank J Fungi (Basel) Review Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a successful clearance of fungal infections; however this perception has been challenged by a large number of studies over the last three decades. In this review, we focus on the potential therapeutic and prophylactic use of monoclonal antibodies. Since systemic mycoses normally occur in severely immunocompromised patients, a passive immunization using monoclonal antibodies is a promising approach to directly attack the fungal pathogen and/or to activate and strengthen the residual antifungal immune response in these patients. MDPI 2020-02-04 /pmc/articles/PMC7151206/ /pubmed/32033168 http://dx.doi.org/10.3390/jof6010022 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ulrich, Sebastian Ebel, Frank Monoclonal Antibodies as Tools to Combat Fungal Infections |
title | Monoclonal Antibodies as Tools to Combat Fungal Infections |
title_full | Monoclonal Antibodies as Tools to Combat Fungal Infections |
title_fullStr | Monoclonal Antibodies as Tools to Combat Fungal Infections |
title_full_unstemmed | Monoclonal Antibodies as Tools to Combat Fungal Infections |
title_short | Monoclonal Antibodies as Tools to Combat Fungal Infections |
title_sort | monoclonal antibodies as tools to combat fungal infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151206/ https://www.ncbi.nlm.nih.gov/pubmed/32033168 http://dx.doi.org/10.3390/jof6010022 |
work_keys_str_mv | AT ulrichsebastian monoclonalantibodiesastoolstocombatfungalinfections AT ebelfrank monoclonalantibodiesastoolstocombatfungalinfections |