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Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT

Betamethasone (BM) administration in pregnancy has been shown to reduce the incidence and severity of neonatal respiratory distress syndrome. Its known diabetogenic impact, combined with placental insulin resistance, leads to a transient increase in glycemia. However, its effect on glucose homeostas...

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Autores principales: Kakoulidis, Ioannis, Ilias, Ioannis, Linardi, Anastasia, Michou, Aikaterini, Milionis, Charalampos, Petychaki, Foteini, Venaki, Evangelia, Koukkou, Eftychia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151230/
https://www.ncbi.nlm.nih.gov/pubmed/32079162
http://dx.doi.org/10.3390/healthcare8010040
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author Kakoulidis, Ioannis
Ilias, Ioannis
Linardi, Anastasia
Michou, Aikaterini
Milionis, Charalampos
Petychaki, Foteini
Venaki, Evangelia
Koukkou, Eftychia
author_facet Kakoulidis, Ioannis
Ilias, Ioannis
Linardi, Anastasia
Michou, Aikaterini
Milionis, Charalampos
Petychaki, Foteini
Venaki, Evangelia
Koukkou, Eftychia
author_sort Kakoulidis, Ioannis
collection PubMed
description Betamethasone (BM) administration in pregnancy has been shown to reduce the incidence and severity of neonatal respiratory distress syndrome. Its known diabetogenic impact, combined with placental insulin resistance, leads to a transient increase in glycemia. However, its effect on glucose homeostasis in pregnancy has not been adequately investigated. We closely monitored and assessed the glycemic profile of 83 pregnant women, with normal glucose metabolism, who were given BM during their hospitalization due to threatened premature labor. A significant change in the glycemic profile in most patients was noted, lasting 1.34 ± 1.05 days. Sixty-six of eighty-three women were eventually treated with insulin to maintain glycemia within acceptable limits. The mean ± SD insulin dosage was 12.25 ± 11.28 units/day. The need for insulin therapy was associated with higher BM doses and the presence of marginal values in the 75-g oral glucose tolerance test (OGTT) at 60 min. Our study demonstrates, following BM administration, the need for increased awareness and individualized monitoring/treatment of pregnant women with normal—yet marginal—values in the 75-g OGTT.
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spelling pubmed-71512302020-04-20 Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT Kakoulidis, Ioannis Ilias, Ioannis Linardi, Anastasia Michou, Aikaterini Milionis, Charalampos Petychaki, Foteini Venaki, Evangelia Koukkou, Eftychia Healthcare (Basel) Article Betamethasone (BM) administration in pregnancy has been shown to reduce the incidence and severity of neonatal respiratory distress syndrome. Its known diabetogenic impact, combined with placental insulin resistance, leads to a transient increase in glycemia. However, its effect on glucose homeostasis in pregnancy has not been adequately investigated. We closely monitored and assessed the glycemic profile of 83 pregnant women, with normal glucose metabolism, who were given BM during their hospitalization due to threatened premature labor. A significant change in the glycemic profile in most patients was noted, lasting 1.34 ± 1.05 days. Sixty-six of eighty-three women were eventually treated with insulin to maintain glycemia within acceptable limits. The mean ± SD insulin dosage was 12.25 ± 11.28 units/day. The need for insulin therapy was associated with higher BM doses and the presence of marginal values in the 75-g oral glucose tolerance test (OGTT) at 60 min. Our study demonstrates, following BM administration, the need for increased awareness and individualized monitoring/treatment of pregnant women with normal—yet marginal—values in the 75-g OGTT. MDPI 2020-02-17 /pmc/articles/PMC7151230/ /pubmed/32079162 http://dx.doi.org/10.3390/healthcare8010040 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kakoulidis, Ioannis
Ilias, Ioannis
Linardi, Anastasia
Michou, Aikaterini
Milionis, Charalampos
Petychaki, Foteini
Venaki, Evangelia
Koukkou, Eftychia
Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title_full Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title_fullStr Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title_full_unstemmed Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title_short Glycemia after Betamethasone in Pregnant Women without Diabetes—Impact of Marginal Values in the 75-g OGTT
title_sort glycemia after betamethasone in pregnant women without diabetes—impact of marginal values in the 75-g ogtt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151230/
https://www.ncbi.nlm.nih.gov/pubmed/32079162
http://dx.doi.org/10.3390/healthcare8010040
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